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PGE2 limits effector expansion of tumour-infiltrating stem-like CD8+ T cells.
Lacher SB, Dörr J, de Almeida GP, Hönninger J, Bayerl F, Hirschberger A, Pedde AM, Meiser P, Ramsauer L, Rudolph TJ, Spranger N, Morotti M, Grimm AJ, Jarosch S, Oner A, Gregor L, Lesch S, Michaelides S, Fertig L, Briukhovetska D, Majed L, Stock S, Busch DH, Buchholz VR, Knolle PA, Zehn D, Dangaj Laniti D, Kobold S, Böttcher JP. Lacher SB, et al. Among authors: zehn d. Nature. 2024 May;629(8011):417-425. doi: 10.1038/s41586-024-07254-x. Epub 2024 Apr 24. Nature. 2024. PMID: 38658748 Free PMC article.
Stat5a sobers up inTOXicated T cells.
Donhauser LV, Zehn D. Donhauser LV, et al. Among authors: zehn d. Immunity. 2023 Dec 12;56(12):2670-2672. doi: 10.1016/j.immuni.2023.11.013. Immunity. 2023. PMID: 38091945
An adrenaline kick to exhaust T cells.
Berner J, Zehn D. Berner J, et al. Among authors: zehn d. Nat Immunol. 2023 Nov;24(11):1792-1793. doi: 10.1038/s41590-023-01650-7. Nat Immunol. 2023. PMID: 37813966 No abstract available.
The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection.
Marx AF, Kallert SM, Brunner TM, Villegas JA, Geier F, Fixemer J, Abreu-Mota T, Reuther P, Bonilla WV, Fadejeva J, Kreutzfeldt M, Wagner I, Aparicio-Domingo P, Scarpellino L, Charmoy M, Utzschneider DT, Hagedorn C, Lu M, Cornille K, Stauffer K, Kreppel F, Merkler D, Zehn D, Held W, Luther SA, Löhning M, Pinschewer DD. Marx AF, et al. Among authors: zehn d. Immunity. 2023 Apr 11;56(4):813-828.e10. doi: 10.1016/j.immuni.2023.01.029. Epub 2023 Feb 20. Immunity. 2023. PMID: 36809763 Free article.
Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development.
Scherer S, Oberle SG, Kanev K, Gerullis AK, Wu M, de Almeida GP, Puleston DJ, Baixauli F, Aly L, Greco A, Nizharadze T, Becker NB, Hoesslin MV, Donhauser LV, Berner J, Chu T, McNamara HA, Esencan Z, Roelli P, Wurmser C, Kleiter I, Vehreschild MJGT, Mayer CA, Knolle P, Klingenspor M, Fumagalli V, Iannacone M, Prlic M, Korn T, Pearce EL, Höfer T, Schulz AM, Zehn D. Scherer S, et al. Among authors: zehn d. Nat Immunol. 2023 Mar;24(3):501-515. doi: 10.1038/s41590-023-01436-x. Epub 2023 Feb 16. Nat Immunol. 2023. PMID: 36797499
Functional T cells are capable of supernumerary cell division and longevity.
Soerens AG, Künzli M, Quarnstrom CF, Scott MC, Swanson L, Locquiao JJ, Ghoneim HE, Zehn D, Youngblood B, Vezys V, Masopust D. Soerens AG, et al. Among authors: zehn d. Nature. 2023 Feb;614(7949):762-766. doi: 10.1038/s41586-022-05626-9. Epub 2023 Jan 18. Nature. 2023. PMID: 36653453
Tapping the keg of discovery to advance T cell therapy.
Schulz AM, Zebley CC, Youngblood B, Zehn D. Schulz AM, et al. Among authors: zehn d. Nat Immunol. 2023 Feb;24(2):213-215. doi: 10.1038/s41590-022-01401-0. Nat Immunol. 2023. PMID: 36631639 Free PMC article.
97 results