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Impaired DNA double-strand break repair and effective radiosensitization of HPV-negative HNSCC cell lines through combined inhibition of PARP and Wee1.
Oetting A, Christiansen S, Gatzemeier F, Köcher S, Bußmann L, Böttcher A, Stölzel K, Hoffmann AS, Struve N, Kriegs M, Petersen C, Betz C, Rothkamm K, Zech HB, Rieckmann T. Oetting A, et al. Among authors: zech hb. Clin Transl Radiat Oncol. 2023 Apr 20;41:100630. doi: 10.1016/j.ctro.2023.100630. eCollection 2023 Jul. Clin Transl Radiat Oncol. 2023. PMID: 37180052 Free PMC article.
A Lack of Effectiveness in the ATM-Orchestrated DNA Damage Response Contributes to the DNA Repair Defect of HPV-Positive Head and Neck Cancer Cells.
Köcher S, Zech HB, Krug L, Gatzemeier F, Christiansen S, Meyer F, Rietow R, Struve N, Mansour WY, Kriegs M, Petersen C, Betz C, Rothkamm K, Rieckmann T. Köcher S, et al. Among authors: zech hb. Front Oncol. 2022 May 31;12:765968. doi: 10.3389/fonc.2022.765968. eCollection 2022. Front Oncol. 2022. PMID: 35719921 Free PMC article.
Patient derived ex vivo tissue slice cultures demonstrate a profound DNA double-strand break repair defect in HPV-positive oropharyngeal head and neck cancer.
Zech HB, Berger J, Mansour WY, Nordquist L, von Bargen CM, Bußmann L, Oetting A, Christiansen S, Möckelmann N, Böttcher A, Busch CJ, Petersen C, Betz C, Rothkamm K, Kriegs M, Köcher S, Rieckmann T. Zech HB, et al. Radiother Oncol. 2022 Mar;168:138-146. doi: 10.1016/j.radonc.2022.01.017. Epub 2022 Jan 29. Radiother Oncol. 2022. PMID: 35093407
Kinomic comparison of snap frozen and ex vivo-cultured head and neck tumors.
Berger J, Zech HB, Hoffer K, von Bargen CM, Nordquist L, Bussmann L, Gatzemeier F, Busch CJ, Möckelmann N, Münscher A, Betz CS, Petersen C, Rothkamm K, Rieckmann T, Köcher S, Kriegs M. Berger J, et al. Among authors: zech hb. Oral Oncol. 2021 Dec;123:105603. doi: 10.1016/j.oraloncology.2021.105603. Epub 2021 Nov 16. Oral Oncol. 2021. PMID: 34798574 Free article.
Analyzing tyrosine kinase activity in head and neck cancer by functional kinomics: Identification of hyperactivated Src family kinases as prognostic markers and potential targets.
Bußmann L, Hoffer K, von Bargen CM, Droste C, Lange T, Kemmling J, Schröder-Schwarz J, Vu AT, Akingunsade L, Nollau P, Rangarajan S, de Wijn R, Oetting A, Müller C, Böckelmann LC, Zech HB, Berger JC, Möckelmann N, Busch CJ, Böttcher A, Gatzemeier F, Klinghammer K, Simnica D, Binder M, Struve N, Rieckmann T, Schumacher U, Clauditz TS, Betz CS, Petersen C, Rothkamm K, Münscher A, Kriegs M. Bußmann L, et al. Among authors: zech hb. Int J Cancer. 2021 Sep 1;149(5):1166-1180. doi: 10.1002/ijc.33606. Epub 2021 May 7. Int J Cancer. 2021. PMID: 33890294 Free article.
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