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Targeting Cancer Metabolism Breaks Radioresistance by Impairing the Stress Response.
Schwab M, Thunborg K, Azimzadeh O, von Toerne C, Werner C, Shevtsov M, Di Genio T, Zdralevic M, Pouyssegur J, Renner K, Kreutz M, Multhoff G. Schwab M, et al. Among authors: zdralevic m. Cancers (Basel). 2021 Jul 27;13(15):3762. doi: 10.3390/cancers13153762. Cancers (Basel). 2021. PMID: 34359663 Free PMC article.
Disrupting glucose-6-phosphate isomerase fully suppresses the "Warburg effect" and activates OXPHOS with minimal impact on tumor growth except in hypoxia.
de Padua MC, Delodi G, Vučetić M, Durivault J, Vial V, Bayer P, Noleto GR, Mazure NM, Ždralević M, Pouysségur J. de Padua MC, et al. Among authors: zdralevic m. Oncotarget. 2017 Sep 18;8(50):87623-87637. doi: 10.18632/oncotarget.21007. eCollection 2017 Oct 20. Oncotarget. 2017. PMID: 29152106 Free PMC article.
Double genetic disruption of lactate dehydrogenases A and B is required to ablate the "Warburg effect" restricting tumor growth to oxidative metabolism.
Ždralević M, Brand A, Di Ianni L, Dettmer K, Reinders J, Singer K, Peter K, Schnell A, Bruss C, Decking SM, Koehl G, Felipe-Abrio B, Durivault J, Bayer P, Evangelista M, O'Brien T, Oefner PJ, Renner K, Pouysségur J, Kreutz M. Ždralević M, et al. J Biol Chem. 2018 Oct 12;293(41):15947-15961. doi: 10.1074/jbc.RA118.004180. Epub 2018 Aug 29. J Biol Chem. 2018. PMID: 30158244 Free PMC article.
Whole-transcriptome Analysis of Fully Viable Energy Efficient Glycolytic-null Cancer Cells Established by Double Genetic Knockout of Lactate Dehydrogenase A/B or Glucose-6-Phosphate Isomerase.
Mazzio E, Badisa R, Mack N, Cassim S, Zdralevic M, Pouyssegur J, Soliman KFA. Mazzio E, et al. Among authors: zdralevic m. Cancer Genomics Proteomics. 2020 Sep-Oct;17(5):469-497. doi: 10.21873/cgp.20205. Cancer Genomics Proteomics. 2020. PMID: 32859627 Free PMC article.
Hypoxia and hypoxia-inducible factors promote the development of neointimal hyperplasia in arteriovenous fistula.
Sadaghianloo N, Contenti J, Declemy S, Ambrosetti D, Zdralevic M, Tannour-Louet M, Fabbri L, Pagès G, Bost F, Hassen-Khodja R, Pouysségur J, Jean-Baptiste E, Dardik A, Mazure NM. Sadaghianloo N, et al. Among authors: zdralevic m. J Physiol. 2021 Apr;599(8):2299-2321. doi: 10.1113/JP281218. Epub 2021 Mar 19. J Physiol. 2021. PMID: 33608879 Free PMC article.
28 results