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Novel Keto-Alkyl-Pyridinium Antifungal Molecules Active in Models of In Vivo Candida albicans Vascular Catheter Infection and Ex Vivo Candida auris Skin Colonization.
Beattie SR, Esan T, Zarnowski R, Eix E, Nett JE, Andes DR, Hagen T, Krysan DJ. Beattie SR, et al. Among authors: zarnowski r. Antimicrob Agents Chemother. 2023 May 17;67(5):e0008123. doi: 10.1128/aac.00081-23. Epub 2023 Apr 25. Antimicrob Agents Chemother. 2023. PMID: 37097144 Free PMC article.
The Candida albicans reference strain SC5314 contains a rare, dominant allele of the transcription factor Rob1 that modulates filamentation, biofilm formation, and oral commensalism.
Glazier VE, Kramara J, Ollinger T, Solis NV, Zarnowski R, Wakade RS, Kim M-J, Weigel GJ, Liang S-H, Bennett RJ, Wellington M, Andes DR, Stamnes MA, Filler SG, Krysan DJ. Glazier VE, et al. Among authors: zarnowski r. mBio. 2023 Oct 31;14(5):e0152123. doi: 10.1128/mbio.01521-23. Epub 2023 Sep 22. mBio. 2023. PMID: 37737633 Free PMC article.
Biofilm-associated metabolism via ERG251 in Candida albicans.
Xiong L, Pereira De Sa N, Zarnowski R, Huang MY, Mota Fernandes C, Lanni F, Andes DR, Del Poeta M, Mitchell AP. Xiong L, et al. Among authors: zarnowski r. PLoS Pathog. 2024 May 13;20(5):e1012225. doi: 10.1371/journal.ppat.1012225. Online ahead of print. PLoS Pathog. 2024. PMID: 38739655 Free article.
Secretion of the fungal toxin candidalysin is dependent on conserved precursor peptide sequences.
Müller R, König A, Groth S, Zarnowski R, Visser C, Handrianz T, Maufrais C, Krüger T, Himmel M, Lee S, Priest EL, Yildirim D, Richardson JP, Blango MG, Bougnoux ME, Kniemeyer O, d'Enfert C, Brakhage AA, Andes DR, Trümper V, Nehls C, Kasper L, Mogavero S, Gutsmann T, Naglik JR, Allert S, Hube B. Müller R, et al. Among authors: zarnowski r. Nat Microbiol. 2024 Mar;9(3):669-683. doi: 10.1038/s41564-024-01606-z. Epub 2024 Feb 22. Nat Microbiol. 2024. PMID: 38388771
Candida albicans extracellular vesicles trigger type I IFN signalling via cGAS and STING.
Brown Harding H, Kwaku GN, Reardon CM, Khan NS, Zamith-Miranda D, Zarnowski R, Tam JM, Bohaen CK, Richey L, Mosallanejad K, Crossen AJ, Reedy JL, Ward RA, Vargas-Blanco DA, Basham KJ, Bhattacharyya RP, Nett JE, Mansour MK, van de Veerdonk FL, Kumar V, Kagan JC, Andes DR, Nosanchuk JD, Vyas JM. Brown Harding H, et al. Among authors: zarnowski r. Nat Microbiol. 2024 Jan;9(1):95-107. doi: 10.1038/s41564-023-01546-0. Epub 2024 Jan 2. Nat Microbiol. 2024. PMID: 38168615 Free PMC article.
Liposomal formulation of a new antifungal hybrid compound provides protection against Candida auris in the ex vivo skin colonization model.
Jaromin A, Zarnowski R, Markowski A, Zagórska A, Johnson CJ, Etezadi H, Kihara S, Mota-Santiago P, Nett JE, Boyd BJ, Andes DR. Jaromin A, et al. Among authors: zarnowski r. Antimicrob Agents Chemother. 2024 Jan 10;68(1):e0095523. doi: 10.1128/aac.00955-23. Epub 2023 Dec 11. Antimicrob Agents Chemother. 2024. PMID: 38092678 Free PMC article.
76 results