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Endocytosis regulates TDP-43 toxicity and turnover.
Liu G, Coyne AN, Pei F, Vaughan S, Chaung M, Zarnescu DC, Buchan JR. Liu G, et al. Among authors: zarnescu dc. Nat Commun. 2017 Dec 12;8(1):2092. doi: 10.1038/s41467-017-02017-x. Nat Commun. 2017. PMID: 29233983 Free PMC article.
PABPN1 suppresses TDP-43 toxicity in ALS disease models.
Chou CC, Alexeeva OM, Yamada S, Pribadi A, Zhang Y, Mo B, Williams KR, Zarnescu DC, Rossoll W. Chou CC, et al. Among authors: zarnescu dc. Hum Mol Genet. 2015 Sep 15;24(18):5154-73. doi: 10.1093/hmg/ddv238. Epub 2015 Jun 30. Hum Mol Genet. 2015. PMID: 26130692 Free PMC article.
Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation.
Coyne AN, Yamada SB, Siddegowda BB, Estes PS, Zaepfel BL, Johannesmeyer JS, Lockwood DB, Pham LT, Hart MP, Cassel JA, Freibaum B, Boehringer AV, Taylor JP, Reitz AB, Gitler AD, Zarnescu DC. Coyne AN, et al. Among authors: zarnescu dc. Hum Mol Genet. 2015 Dec 15;24(24):6886-98. doi: 10.1093/hmg/ddv389. Epub 2015 Sep 18. Hum Mol Genet. 2015. PMID: 26385636 Free PMC article.
Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS.
Coyne AN, Lorenzini I, Chou CC, Torvund M, Rogers RS, Starr A, Zaepfel BL, Levy J, Johannesmeyer J, Schwartz JC, Nishimune H, Zinsmaier K, Rossoll W, Sattler R, Zarnescu DC. Coyne AN, et al. Among authors: zarnescu dc. Cell Rep. 2017 Oct 3;21(1):110-125. doi: 10.1016/j.celrep.2017.09.028. Cell Rep. 2017. PMID: 28978466 Free PMC article.
53 results