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316 results

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Hypoxia as a therapy for mitochondrial disease.
Jain IH, Zazzeron L, Goli R, Alexa K, Schatzman-Bone S, Dhillon H, Goldberger O, Peng J, Shalem O, Sanjana NE, Zhang F, Goessling W, Zapol WM, Mootha VK. Jain IH, et al. Among authors: zapol wm. Science. 2016 Apr 1;352(6281):54-61. doi: 10.1126/science.aad9642. Epub 2016 Feb 25. Science. 2016. PMID: 26917594 Free PMC article.
Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome.
Ferrari M, Jain IH, Goldberger O, Rezoagli E, Thoonen R, Cheng KH, Sosnovik DE, Scherrer-Crosbie M, Mootha VK, Zapol WM. Ferrari M, et al. Among authors: zapol wm. Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4241-E4250. doi: 10.1073/pnas.1621511114. Epub 2017 May 8. Proc Natl Acad Sci U S A. 2017. PMID: 28483998 Free PMC article.
Impaired hypoxic pulmonary vasoconstriction in a mouse model of Leigh syndrome.
Schleifer G, Marutani E, Ferrari M, Sharma R, Skinner O, Goldberger O, Grange RMH, Peneyra K, Malhotra R, Wepler M, Ichinose F, Bloch DB, Mootha VK, Zapol WM. Schleifer G, et al. Among authors: zapol wm. Am J Physiol Lung Cell Mol Physiol. 2019 Feb 1;316(2):L391-L399. doi: 10.1152/ajplung.00419.2018. Epub 2018 Dec 6. Am J Physiol Lung Cell Mol Physiol. 2019. PMID: 30520688 Free PMC article.
Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation.
Jain IH, Zazzeron L, Goldberger O, Marutani E, Wojtkiewicz GR, Ast T, Wang H, Schleifer G, Stepanova A, Brepoels K, Schoonjans L, Carmeliet P, Galkin A, Ichinose F, Zapol WM, Mootha VK. Jain IH, et al. Among authors: zapol wm. Cell Metab. 2019 Oct 1;30(4):824-832.e3. doi: 10.1016/j.cmet.2019.07.006. Epub 2019 Aug 8. Cell Metab. 2019. PMID: 31402314 Free PMC article.
Hypoxia ameliorates brain hyperoxia and NAD+ deficiency in a murine model of Leigh syndrome.
Grange RMH, Sharma R, Shah H, Reinstadler B, Goldberger O, Cooper MK, Nakagawa A, Miyazaki Y, Hindle AG, Batten AJ, Wojtkiewicz GR, Schleifer G, Bagchi A, Marutani E, Malhotra R, Bloch DB, Ichinose F, Mootha VK, Zapol WM. Grange RMH, et al. Among authors: zapol wm. Mol Genet Metab. 2021 May;133(1):83-93. doi: 10.1016/j.ymgme.2021.03.005. Epub 2021 Mar 11. Mol Genet Metab. 2021. PMID: 33752971 Free PMC article.
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis.
Ast T, Meisel JD, Patra S, Wang H, Grange RMH, Kim SH, Calvo SE, Orefice LL, Nagashima F, Ichinose F, Zapol WM, Ruvkun G, Barondeau DP, Mootha VK. Ast T, et al. Among authors: zapol wm. Cell. 2019 May 30;177(6):1507-1521.e16. doi: 10.1016/j.cell.2019.03.045. Epub 2019 Apr 25. Cell. 2019. PMID: 31031004 Free PMC article.
Pulmonary Phototherapy for Treating Carbon Monoxide Poisoning.
Zazzeron L, Liu C, Franco W, Nakagawa A, Farinelli WA, Bloch DB, Anderson RR, Zapol WM. Zazzeron L, et al. Among authors: zapol wm. Am J Respir Crit Care Med. 2015 Nov 15;192(10):1191-9. doi: 10.1164/rccm.201503-0609OC. Am J Respir Crit Care Med. 2015. PMID: 26214119 Free PMC article.
Pulmonary Phototherapy to Treat Carbon Monoxide Poisoning in Rats.
Zazzeron L, Liu C, Franco W, Nakagawa A, Farinelli WA, Bloch DB, Anderson RR, Zapol WM. Zazzeron L, et al. Among authors: zapol wm. Shock. 2017 Jun;47(6):735-742. doi: 10.1097/SHK.0000000000000797. Shock. 2017. PMID: 27861257 Free PMC article.
316 results