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The lectin DrfL inhibits cell migration, adhesion and triggers autophagy-dependent cell death in glioma cells.
Wolin IAV, Nascimento APM, Seeger R, Poluceno GG, Zanotto-Filho A, Nedel CB, Tasca CI, Correia SEG, Oliveira MV, Pinto-Junior VR, Osterne VJS, Nascimento KS, Cavada BS, Leal RB. Wolin IAV, et al. Among authors: zanotto filho a. Glycoconj J. 2023 Feb;40(1):47-67. doi: 10.1007/s10719-022-10095-3. Epub 2022 Dec 16. Glycoconj J. 2023. PMID: 36522582
Lectin from Dioclea violacea induces autophagy in U87 glioma cells.
Nascimento APM, Wolin IAV, Welter PG, Heinrich IA, Zanotto-Filho A, Osterne VJS, Lossio CF, Silva MTL, Nascimento KS, Cavada BS, Leal RB. Nascimento APM, et al. Int J Biol Macromol. 2019 Aug 1;134:660-672. doi: 10.1016/j.ijbiomac.2019.04.203. Epub 2019 May 1. Int J Biol Macromol. 2019. PMID: 31054301 Free article.
ConBr lectin modulates MAPKs and Akt pathways and triggers autophagic glioma cell death by a mechanism dependent upon caspase-8 activation.
Wolin IAV, Heinrich IA, Nascimento APM, Welter PG, Sosa LDV, De Paul AL, Zanotto-Filho A, Nedel CB, Lima LD, Osterne VJS, Pinto-Junior VR, Nascimento KS, Cavada BS, Leal RB. Wolin IAV, et al. Among authors: zanotto filho a. Biochimie. 2021 Jan;180:186-204. doi: 10.1016/j.biochi.2020.11.003. Epub 2020 Nov 7. Biochimie. 2021. PMID: 33171216 Free article.
NFκB inhibitors induce cell death in glioblastomas.
Zanotto-Filho A, Braganhol E, Schröder R, de Souza LH, Dalmolin RJ, Pasquali MA, Gelain DP, Battastini AM, Moreira JC. Zanotto-Filho A, et al. Biochem Pharmacol. 2011 Feb 1;81(3):412-24. doi: 10.1016/j.bcp.2010.10.014. Epub 2010 Oct 30. Biochem Pharmacol. 2011. PMID: 21040711
Efficient identification of novel anti-glioma lead compounds by machine learning models.
Neves BJ, Agnes JP, Gomes MDN, Henriques Donza MR, Gonçalves RM, Delgobo M, Ribeiro de Souza Neto L, Senger MR, Silva-Junior FP, Ferreira SB, Zanotto-Filho A, Andrade CH. Neves BJ, et al. Eur J Med Chem. 2020 Mar 1;189:111981. doi: 10.1016/j.ejmech.2019.111981. Epub 2019 Dec 19. Eur J Med Chem. 2020. PMID: 31978780
63 results