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Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-κB-driven inflammation and cardiovascular risk.
Zannas AS, Jia M, Hafner K, Baumert J, Wiechmann T, Pape JC, Arloth J, Ködel M, Martinelli S, Roitman M, Röh S, Haehle A, Emeny RT, Iurato S, Carrillo-Roa T, Lahti J, Räikkönen K, Eriksson JG, Drake AJ, Waldenberger M, Wahl S, Kunze S, Lucae S, Bradley B, Gieger C, Hausch F, Smith AK, Ressler KJ, Müller-Myhsok B, Ladwig KH, Rein T, Gassen NC, Binder EB. Zannas AS, et al. Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11370-11379. doi: 10.1073/pnas.1816847116. Epub 2019 May 21. Proc Natl Acad Sci U S A. 2019. PMID: 31113877 Free PMC article.
Selective inhibitors of the FK506-binding protein 51 by induced fit.
Gaali S, Kirschner A, Cuboni S, Hartmann J, Kozany C, Balsevich G, Namendorf C, Fernandez-Vizarra P, Sippel C, Zannas AS, Draenert R, Binder EB, Almeida OF, Rühter G, Uhr M, Schmidt MV, Touma C, Bracher A, Hausch F. Gaali S, et al. Among authors: zannas as. Nat Chem Biol. 2015 Jan;11(1):33-7. doi: 10.1038/nchembio.1699. Epub 2014 Dec 1. Nat Chem Biol. 2015. PMID: 25436518
FKBP51 inhibits GSK3β and augments the effects of distinct psychotropic medications.
Gassen NC, Hartmann J, Zannas AS, Kretzschmar A, Zschocke J, Maccarrone G, Hafner K, Zellner A, Kollmannsberger LK, Wagner KV, Mehta D, Kloiber S, Turck CW, Lucae S, Chrousos GP, Holsboer F, Binder EB, Ising M, Schmidt MV, Rein T. Gassen NC, et al. Among authors: zannas as. Mol Psychiatry. 2016 Feb;21(2):277-89. doi: 10.1038/mp.2015.38. Epub 2015 Apr 7. Mol Psychiatry. 2016. PMID: 25849320
Chaperoning epigenetics: FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine.
Gassen NC, Fries GR, Zannas AS, Hartmann J, Zschocke J, Hafner K, Carrillo-Roa T, Steinbacher J, Preißinger SN, Hoeijmakers L, Knop M, Weber F, Kloiber S, Lucae S, Chrousos GP, Carell T, Ising M, Binder EB, Schmidt MV, Rüegg J, Rein T. Gassen NC, et al. Among authors: zannas as. Sci Signal. 2015 Nov 24;8(404):ra119. doi: 10.1126/scisignal.aac7695. Sci Signal. 2015. PMID: 26602018
64 results