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Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche.
Dawson A, Zarou MM, Prasad B, Bittencourt-Silvestre J, Zerbst D, Himonas E, Hsieh YC, van Loon I, Blanco GR, Ianniciello A, Kerekes Z, Krishnan V, Agarwal P, Almasoudi H, McCluskey L, Hopcroft LEM, Scott MT, Baquero P, Dunn K, Vetrie D, Copland M, Bhatia R, Coffelt SB, Tiong OS, Wheadon H, Zanivan S, Kirschner K, Helgason GV. Dawson A, et al. Among authors: zanivan s. Nat Commun. 2024 Feb 5;15(1):1090. doi: 10.1038/s41467-024-45471-0. Nat Commun. 2024. PMID: 38316788 Free PMC article.
Mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade response in melanoma.
Mahmood M, Liu EM, Shergold AL, Tolla E, Tait-Mulder J, Huerta-Uribe A, Shokry E, Young AL, Lilla S, Kim M, Park T, Boscenco S, Manchon JL, Rodríguez-Antona C, Walters RC, Springett RJ, Blaza JN, Mitchell L, Blyth K, Zanivan S, Sumpton D, Roberts EW, Reznik E, Gammage PA. Mahmood M, et al. Among authors: zanivan s. Nat Cancer. 2024 Apr;5(4):659-672. doi: 10.1038/s43018-023-00721-w. Epub 2024 Jan 29. Nat Cancer. 2024. PMID: 38286828 Free PMC article.
The helminth TGF-β mimic TGM4 is a modular ligand that binds CD44, CD49d and TGF-β receptors to preferentially target myeloid cells.
Singh SP, Smyth DJ, Cunningham K, Mukundan A, Byeon CH, Hinck CS, White MPJ, Ciancia C, Wosowska N, Sanders A, Jin R, Lilla S, Zanivan S, Schoenherr C, Inman G, van Dinther M, Ten Dijke P, Hinck AP, Maizels RM. Singh SP, et al. Among authors: zanivan s. bioRxiv [Preprint]. 2023 Nov 15:2023.11.13.566701. doi: 10.1101/2023.11.13.566701. bioRxiv. 2023. PMID: 38014296 Free PMC article. Preprint.
STIM1 translocation to the nucleus protects cells from DNA damage.
Sanchez-Lopez I, Orantos-Aguilera Y, Pozo-Guisado E, Alvarez-Barrientos A, Lilla S, Zanivan S, Lachaud C, Martin-Romero FJ. Sanchez-Lopez I, et al. Among authors: zanivan s. Nucleic Acids Res. 2024 Mar 21;52(5):2389-2415. doi: 10.1093/nar/gkae001. Nucleic Acids Res. 2024. PMID: 38224453 Free PMC article.
Omentum-derived matrix enables the study of metastatic ovarian cancer and stromal cell functions in a physiologically relevant environment.
Neilson LJ, Cartwright D, Risteli M, Jokinen EM, McGarry L, Sandvik T, Nikolatou K, Hodge K, Atkinson S, Vias M, Kay EJ, Brenton JD, Carlin LM, Bryant DM, Salo T, Zanivan S. Neilson LJ, et al. Among authors: zanivan s. Matrix Biol Plus. 2023 Nov 22;19-20:100136. doi: 10.1016/j.mbplus.2023.100136. eCollection 2023 Dec. Matrix Biol Plus. 2023. PMID: 38223308 Free PMC article.
Tumour mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade.
Mahmood M, Liu EM, Shergold AL, Tolla E, Tait-Mulder J, Huerta Uribe A, Shokry E, Young AL, Lilla S, Kim M, Park T, Manchon JL, Rodríguez-Antona C, Walters RC, Springett RJ, Blaza JN, Zanivan S, Sumpton D, Roberts EW, Reznik E, Gammage PA. Mahmood M, et al. Among authors: zanivan s. bioRxiv [Preprint]. 2023 Mar 23:2023.03.21.533091. doi: 10.1101/2023.03.21.533091. bioRxiv. 2023. PMID: 36993533 Free PMC article. Updated. Preprint.
Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function.
Santi A, Kay EJ, Neilson LJ, McGarry L, Lilla S, Mullin M, Paul NR, Fercoq F, Koulouras G, Rodriguez Blanco G, Athineos D, Mason S, Hughes M, Thomson G, Kieffer Y, Nixon C, Blyth K, Mechta-Grigoriou F, Carlin LM, Zanivan S. Santi A, et al. Among authors: zanivan s. Sci Signal. 2024 Mar 12;17(827):eade0580. doi: 10.1126/scisignal.ade0580. Epub 2024 Mar 12. Sci Signal. 2024. PMID: 38470957
91 results