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Lipid Nanoparticle-Associated Inflammation is Triggered by Sensing of Endosomal Damage: Engineering Endosomal Escape Without Side Effects.
Omo-Lamai S, Wang Y, Patel MN, Essien EO, Shen M, Majumdar A, Espy C, Wu J, Channer B, Tobin M, Murali S, Papp TE, Maheshwari R, Wang L, Chase LS, Zamora ME, Arral ML, Marcos-Contreras OA, Myerson JW, Hunter CA, Tsourkas A, Muzykantov V, Brodsky I, Shin S, Whitehead KA, Gaskill P, Discher D, Parhiz H, Brenner JS. Omo-Lamai S, et al. Among authors: zamora me. bioRxiv [Preprint]. 2024 Apr 18:2024.04.16.589801. doi: 10.1101/2024.04.16.589801. bioRxiv. 2024. PMID: 38659905 Free PMC article. Preprint.
Targeting lipid nanoparticles to the blood-brain barrier to ameliorate acute ischemic stroke.
Nong J, Glassman PM, Shuvaev VV, Reyes-Esteves S, Descamps HC, Kiseleva RY, Papp TE, Alameh MG, Tam YK, Mui BL, Omo-Lamai S, Zamora ME, Shuvaeva T, Arguiri E, Gong X, Brysgel TV, Tan AW, Woolfork AG, Weljie A, Thaiss CA, Myerson JW, Weissman D, Kasner SE, Parhiz H, Muzykantov VR, Brenner JS, Marcos-Contreras OA. Nong J, et al. Among authors: zamora me. Mol Ther. 2024 Mar 7:S1525-0016(24)00145-X. doi: 10.1016/j.ymthe.2024.03.004. Online ahead of print. Mol Ther. 2024. PMID: 38454606
Targeted Nanocarriers Co-Opting Pulmonary Intravascular Leukocytes for Drug Delivery to the Injured Brain.
Nong J, Glassman PM, Myerson JW, Zuluaga-Ramirez V, Rodriguez-Garcia A, Mukalel A, Omo-Lamai S, Walsh LR, Zamora ME, Gong X, Wang Z, Bhamidipati K, Kiseleva RY, Villa CH, Greineder CF, Kasner SE, Weissman D, Mitchell MJ, Muro S, Persidsky Y, Brenner JS, Muzykantov VR, Marcos-Contreras OA. Nong J, et al. Among authors: zamora me. ACS Nano. 2023 Jul 25;17(14):13121-13136. doi: 10.1021/acsnano.2c08275. Epub 2023 Jul 11. ACS Nano. 2023. PMID: 37432926 Free article.
Targeting lipid nanoparticles to the blood brain barrier to ameliorate acute ischemic stroke.
Nong J, Glassman PM, Reyes-Esteves S, Descamps HC, Shuvaev VV, Kiseleva RY, Papp TE, Alameh MG, Tam YK, Mui BL, Omo-Lamai S, Zamora ME, Shuvaeva T, Arguiri E, Thaiss CA, Myerson JW, Weissman D, Kasner SE, Parhiz H, Muzykantov VR, Brenner JS, Marcos-Contreras OA. Nong J, et al. Among authors: zamora me. bioRxiv [Preprint]. 2023 Jun 13:2023.06.12.544645. doi: 10.1101/2023.06.12.544645. bioRxiv. 2023. PMID: 37398465 Free PMC article. Updated. Preprint.
Mechanisms by Which Liposomes Improve Inhaled Drug Delivery for Alveolar Diseases.
Ferguson LT, Ma X, Myerson JW, Wu J, Glassman PM, Zamora ME, Hood ED, Zaleski M, Shen M, Essien EO, Shuvaev VV, Brenner JS. Ferguson LT, et al. Among authors: zamora me. Adv Nanobiomed Res. 2023 Mar;3(3):2200106. doi: 10.1002/anbr.202200106. Epub 2023 Jan 27. Adv Nanobiomed Res. 2023. PMID: 37266328 Free PMC article.
Targeted drug delivery to the brain endothelium dominates over passive delivery via vascular leak in experimental intracerebral hemorrhage.
Reyes-Esteves S, Nong J, Glassman PM, Omo-Lamai S, Ohashi S, Myerson JW, Zamora ME, Ma X, Kasner SE, Sansing L, Muzykantov VR, Marcos-Contreras OA, Brenner JS. Reyes-Esteves S, et al. Among authors: zamora me. J Control Release. 2023 Apr;356:185-195. doi: 10.1016/j.jconrel.2023.02.037. Epub 2023 Mar 7. J Control Release. 2023. PMID: 36868517 Free PMC article.
Added to pre-existing inflammation, mRNA-lipid nanoparticles induce inflammation exacerbation (IE).
Parhiz H, Brenner JS, Patel PN, Papp TE, Shahnawaz H, Li Q, Shi R, Zamora ME, Yadegari A, Marcos-Contreras OA, Natesan A, Pardi N, Shuvaev VV, Kiseleva R, Myerson JW, Uhler T, Riley RS, Han X, Mitchell MJ, Lam K, Heyes J, Weissman D, Muzykantov VR. Parhiz H, et al. Among authors: zamora me. J Control Release. 2022 Apr;344:50-61. doi: 10.1016/j.jconrel.2021.12.027. Epub 2021 Dec 23. J Control Release. 2022. PMID: 34953981 Free PMC article.
15 results