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Lipophilic Peptide Dendrimers for Delivery of Splice-Switching Oligonucleotides.
Daralnakhla H, Saher O, Zamolo S, Bazaz S, P Bost J, Heitz M, Lundin KE, El Andaloussi S, Darbre T, Reymond JL, Zain R, Smith CIE. Daralnakhla H, et al. Among authors: zain r. Pharmaceutics. 2021 Jan 18;13(1):116. doi: 10.3390/pharmaceutics13010116. Pharmaceutics. 2021. PMID: 33477663 Free PMC article.
Development of bis-locked nucleic acid (bisLNA) oligonucleotides for efficient invasion of supercoiled duplex DNA.
Moreno PM, Geny S, Pabon YV, Bergquist H, Zaghloul EM, Rocha CS, Oprea II, Bestas B, Andaloussi SE, Jørgensen PT, Pedersen EB, Lundin KE, Zain R, Wengel J, Smith CI. Moreno PM, et al. Among authors: zain r. Nucleic Acids Res. 2013 Mar 1;41(5):3257-73. doi: 10.1093/nar/gkt007. Epub 2013 Jan 23. Nucleic Acids Res. 2013. PMID: 23345620 Free PMC article.
Next-generation bis-locked nucleic acids with stacking linker and 2'-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes.
Geny S, Moreno PM, Krzywkowski T, Gissberg O, Andersen NK, Isse AJ, El-Madani AM, Lou C, Pabon YV, Anderson BA, Zaghloul EM, Zain R, Hrdlicka PJ, Jørgensen PT, Nilsson M, Lundin KE, Pedersen EB, Wengel J, Smith CI. Geny S, et al. Among authors: zain r. Nucleic Acids Res. 2016 Mar 18;44(5):2007-19. doi: 10.1093/nar/gkw021. Epub 2016 Feb 8. Nucleic Acids Res. 2016. PMID: 26857548 Free PMC article.
CTG repeat-targeting oligonucleotides for down-regulating Huntingtin expression.
Zaghloul EM, Gissberg O, Moreno PMD, Siggens L, Hällbrink M, Jørgensen AS, Ekwall K, Zain R, Wengel J, Lundin KE, Smith CIE. Zaghloul EM, et al. Among authors: zain r. Nucleic Acids Res. 2017 May 19;45(9):5153-5169. doi: 10.1093/nar/gkx111. Nucleic Acids Res. 2017. PMID: 28334749 Free PMC article.
Novel peptide-dendrimer/lipid/oligonucleotide ternary complexes for efficient cellular uptake and improved splice-switching activity.
Saher O, Rocha CSJ, Zaghloul EM, Wiklander OPB, Zamolo S, Heitz M, Ezzat K, Gupta D, Reymond JL, Zain R, Hollfelder F, Darbre T, Lundin KE, El Andaloussi S, Smith CIE. Saher O, et al. Among authors: zain r. Eur J Pharm Biopharm. 2018 Nov;132:29-40. doi: 10.1016/j.ejpb.2018.09.002. Epub 2018 Sep 4. Eur J Pharm Biopharm. 2018. PMID: 30193928
211 results