Zahid H - Search Results

1

Development of an N-Terminal BRD4 Bromodomain-Targeted Degrader.

Divakaran A, Scholtz CR, Zahid H, Lin W, Griffith EC, Lee RE, Chen T, Harki DA, Pomerantz WCK. Divakaran A, et al. Among authors: zahid h. ACS Med Chem Lett. 2022 Sep 29;13(10):1621-1627. doi: 10.1021/acsmedchemlett.2c00300. eCollection 2022 Oct 13. ACS Med Chem Lett. 2022. PMID: 36262390 Free PMC article.

2

Selectivity, ligand deconstruction, and cellular activity analysis of a BPTF bromodomain inhibitor.

Kirberger SE, Ycas PD, Johnson JA, Chen C, Ciccone MF, Woo RWL, Urick AK, Zahid H, Shi K, Aihara H, McAllister SD, Kashani-Sabet M, Shi J, Dickson A, Dos Santos CO, Pomerantz WCK. Kirberger SE, et al. Among authors: zahid h. Org Biomol Chem. 2019 Feb 13;17(7):2020-2027. doi: 10.1039/c8ob02599a. Org Biomol Chem. 2019. PMID: 30706071 Free PMC article.

3

NMR Analyses of Acetylated H2A.Z Isoforms Identify Differential Binding Interactions with the Bromodomain of the NURF Nucleosome Remodeling Complex.

Olson NM, Kroc S, Johnson JA, Zahid H, Ycas PD, Chan A, Kimbrough JR, Kalra P, Schönbrunn E, Pomerantz WCK. Olson NM, et al. Among authors: zahid h. Biochemistry. 2020 May 26;59(20):1871-1880. doi: 10.1021/acs.biochem.0c00159. Epub 2020 May 11. Biochemistry. 2020. PMID: 32356653 Free PMC article.

4

New inhibitors for the BPTF bromodomain enabled by structural biology and biophysical assay development.

Ycas PD, Zahid H, Chan A, Olson NM, Johnson JA, Talluri SK, Schonbrunn E, Pomerantz WCK. Ycas PD, et al. Among authors: zahid h. Org Biomol Chem. 2020 Jul 15;18(27):5174-5182. doi: 10.1039/d0ob00506a. Org Biomol Chem. 2020. PMID: 32588860 Free PMC article.

5

Selective N-Terminal BET Bromodomain Inhibitors by Targeting Non-Conserved Residues and Structured Water Displacement*.

Cui H, Divakaran A, Pandey AK, Johnson JA, Zahid H, Hoell ZJ, Ellingson MO, Shi K, Aihara H, Harki DA, Pomerantz WCK. Cui H, et al. Among authors: zahid h. Angew Chem Int Ed Engl. 2021 Jan 18;60(3):1220-1226. doi: 10.1002/anie.202008625. Epub 2020 Nov 18. Angew Chem Int Ed Engl. 2021. PMID: 32975004 Free PMC article.

6

Opportunity knocks for uncovering the new function of an understudied nucleosome remodeling complex member, the bromodomain PHD finger transcription factor, BPTF.

Zahid H, Olson NM, Pomerantz WCK. Zahid H, et al. Curr Opin Chem Biol. 2021 Aug;63:57-67. doi: 10.1016/j.cbpa.2021.02.003. Epub 2021 Mar 8. Curr Opin Chem Biol. 2021. PMID: 33706239 Free PMC article. Review.

7

4-Methyl-1,2,3-Triazoles as N-Acetyl-Lysine Mimics Afford Potent BET Bromodomain Inhibitors with Improved Selectivity.

Cui H, Carlson AS, Schleiff MA, Divakaran A, Johnson JA, Buchholz CR, Zahid H, Vail NR, Shi K, Aihara H, Harki DA, Miller GP, Topczewski JJ, Pomerantz WCK. Cui H, et al. Among authors: zahid h. J Med Chem. 2021 Jul 22;64(14):10497-10511. doi: 10.1021/acs.jmedchem.1c00933. Epub 2021 Jul 8. J Med Chem. 2021. PMID: 34236185 Free PMC article.

8

New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition.

Zahid H, Buchholz CR, Singh M, Ciccone MF, Chan A, Nithianantham S, Shi K, Aihara H, Fischer M, Schönbrunn E, Dos Santos CO, Landry JW, Pomerantz WCK. Zahid H, et al. J Med Chem. 2021 Sep 23;64(18):13902-13917. doi: 10.1021/acs.jmedchem.1c01294. Epub 2021 Sep 13. J Med Chem. 2021. PMID: 34515477 Free PMC article.

9

A Structure-based Design Approach for Generating High Affinity BRD4 D1-Selective Chemical Probes.

Cui H, Divakaran A, Hoell ZJ, Ellingson MO, Scholtz CR, Zahid H, Johnson JA, Griffith EC, Gee CT, Lee AL, Khanal S, Shi K, Aihara H, Shah VH, Lee RE, Harki DA, Pomerantz WCK. Cui H, et al. Among authors: zahid h. J Med Chem. 2022 Feb 10;65(3):2342-2360. doi: 10.1021/acs.jmedchem.1c01779. Epub 2022 Jan 10. J Med Chem. 2022. PMID: 35007061 Free PMC article.

10

Alternative Mechanisms for DNA Engagement by BET Bromodomain-Containing Proteins.

Kalra P, Zahid H, Ayoub A, Dou Y, Pomerantz WCK. Kalra P, et al. Among authors: zahid h. Biochemistry. 2022 Jul 5;61(13):1260-1272. doi: 10.1021/acs.biochem.2c00157. Epub 2022 Jun 24. Biochemistry. 2022. PMID: 35748495 Free PMC article.

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