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New arylpiperazinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and dihydro[1,3]oxazolo[2,3-f]purinedione targeting the serotonin 5-HT1A /5-HT2A /5-HT7 and dopamine D2 receptors.
Chłoń-Rzepa G, Zagórska A, Bucki A, Kołaczkowski M, Pawłowski M, Satała G, Bojarski AJ, Partyka A, Wesołowska A, Pękala E, Słoczyńska K. Chłoń-Rzepa G, et al. Among authors: zagorska a. Arch Pharm (Weinheim). 2015 Apr;348(4):242-53. doi: 10.1002/ardp.201500015. Epub 2015 Mar 13. Arch Pharm (Weinheim). 2015. PMID: 25773907
Synthesis and biological evaluation of 2-fluoro and 3-trifluoromethyl-phenyl-piperazinylalkyl derivatives of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione as potential antidepressant agents.
Zagórska A, Bucki A, Kołaczkowski M, Siwek A, Głuch-Lutwin M, Starowicz G, Kazek G, Partyka A, Wesołowska A, Słoczyńska K, Pękala E, Pawłowski M. Zagórska A, et al. J Enzyme Inhib Med Chem. 2016;31(sup3):10-24. doi: 10.1080/14756366.2016.1198902. Epub 2016 Jun 29. J Enzyme Inhib Med Chem. 2016. PMID: 27353547
Aminoalkyl Derivatives of 8-Alkoxypurine-2,6-diones: Multifunctional 5-HT1A /5-HT7 Receptor Ligands and PDE Inhibitors with Antidepressant Activity.
Chłoń-Rzepa G, Zagórska A, Żmudzki P, Bucki A, Kołaczkowski M, Partyka A, Wesołowska A, Kazek G, Głuch-Lutwin M, Siwek A, Starowicz G, Pawłowski M. Chłoń-Rzepa G, et al. Among authors: zagorska a. Arch Pharm (Weinheim). 2016 Dec;349(12):889-903. doi: 10.1002/ardp.201600260. Epub 2016 Nov 21. Arch Pharm (Weinheim). 2016. PMID: 27869315
Synthesis and biological evaluation of N-arylpiperazine derivatives of 4,4-dimethylisoquinoline-1,3(2H,4H)-dione as potential antiplatelet agents.
Marcinkowska M, Kotańska M, Zagórska A, Śniecikowska J, Kubacka M, Siwek A, Bucki A, Pawłowski M, Bednarski M, Sapa J, Starek M, Dąbrowska M, Kołaczkowski M. Marcinkowska M, et al. Among authors: zagorska a. J Enzyme Inhib Med Chem. 2018 Dec;33(1):536-545. doi: 10.1080/14756366.2018.1437155. J Enzyme Inhib Med Chem. 2018. PMID: 29482394 Free PMC article.
Characteristics of metabolic stability and the cell permeability of 2-pyrimidinyl-piperazinyl-alkyl derivatives of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione with antidepressant- and anxiolytic-like activities.
Zagórska A, Partyka A, Bucki A, Kołaczkowski M, Jastrzębska-Więsek M, Czopek A, Siwek A, Głuch-Lutwin M, Bednarski M, Bajda M, Jończyk J, Piska K, Koczurkiewicz P, Wesołowska A, Pawłowski M. Zagórska A, et al. Chem Biol Drug Des. 2019 Apr;93(4):511-521. doi: 10.1111/cbdd.13442. Epub 2018 Dec 4. Chem Biol Drug Des. 2019. PMID: 30422400
Novel multitarget 5-arylidenehydantoins with arylpiperazinealkyl fragment: Pharmacological evaluation and investigation of cytotoxicity and metabolic stability.
Czopek A, Bucki A, Kołaczkowski M, Zagórska A, Drop M, Pawłowski M, Siwek A, Głuch-Lutwin M, Pękala E, Chrzanowska A, Struga M, Partyka A, Wesołowska A. Czopek A, et al. Among authors: zagorska a. Bioorg Med Chem. 2019 Sep 15;27(18):4163-4173. doi: 10.1016/j.bmc.2019.07.046. Epub 2019 Jul 30. Bioorg Med Chem. 2019. PMID: 31383628
Multifunctional 6-fluoro-3-[3-(pyrrolidin-1-yl)propyl]-1,2-benzoxazoles targeting behavioral and psychological symptoms of dementia (BPSD).
Bucki A, Marcinkowska M, Śniecikowska J, Zagórska A, Jamrozik M, Pawłowski M, Głuch-Lutwin M, Siwek A, Jakubczyk M, Pytka K, Jastrzębska-Więsek M, Partyka A, Wesołowska A, Mierzejewski P, Kołaczkowski M. Bucki A, et al. Among authors: zagorska a. Eur J Med Chem. 2020 Apr 1;191:112149. doi: 10.1016/j.ejmech.2020.112149. Epub 2020 Feb 18. Eur J Med Chem. 2020. PMID: 32105980 Free article.
Impact of N-Alkylamino Substituents on Serotonin Receptor (5-HTR) Affinity and Phosphodiesterase 10A (PDE10A) Inhibition of Isoindole-1,3-dione Derivatives.
Czopek A, Partyka A, Bucki A, Pawłowski M, Kołaczkowski M, Siwek A, Głuch-Lutwin M, Koczurkiewicz P, Pękala E, Jaromin A, Tyliszczak B, Wesołowska A, Zagórska A. Czopek A, et al. Among authors: zagorska a. Molecules. 2020 Aug 25;25(17):3868. doi: 10.3390/molecules25173868. Molecules. 2020. PMID: 32854402 Free PMC article.
87 results