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SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence.
Gioia U, Tavella S, Martínez-Orellana P, Cicio G, Colliva A, Ceccon M, Cabrini M, Henriques AC, Fumagalli V, Paldino A, Presot E, Rajasekharan S, Iacomino N, Pisati F, Matti V, Sepe S, Conte MI, Barozzi S, Lavagnino Z, Carletti T, Volpe MC, Cavalcante P, Iannacone M, Rampazzo C, Bussani R, Tripodo C, Zacchigna S, Marcello A, d'Adda di Fagagna F. Gioia U, et al. Among authors: zacchigna s. Nat Cell Biol. 2023 Apr;25(4):550-564. doi: 10.1038/s41556-023-01096-x. Epub 2023 Mar 9. Nat Cell Biol. 2023. PMID: 36894671 Free PMC article.
Matrix-binding vascular endothelial growth factor (VEGF) isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1.
Ruiz de Almodovar C, Coulon C, Salin PA, Knevels E, Chounlamountri N, Poesen K, Hermans K, Lambrechts D, Van Geyte K, Dhondt J, Dresselaers T, Renaud J, Aragones J, Zacchigna S, Geudens I, Gall D, Stroobants S, Mutin M, Dassonville K, Storkebaum E, Jordan BF, Eriksson U, Moons L, D'Hooge R, Haigh JJ, Belin MF, Schiffmann S, Van Hecke P, Gallez B, Vinckier S, Chédotal A, Honnorat J, Thomasset N, Carmeliet P, Meissirel C. Ruiz de Almodovar C, et al. Among authors: zacchigna s. J Neurosci. 2010 Nov 10;30(45):15052-66. doi: 10.1523/JNEUROSCI.0477-10.2010. J Neurosci. 2010. PMID: 21068311 Free PMC article.
Impaired autonomic regulation of resistance arteries in mice with low vascular endothelial growth factor or upon vascular endothelial growth factor trap delivery.
Storkebaum E, Ruiz de Almodovar C, Meens M, Zacchigna S, Mazzone M, Vanhoutte G, Vinckier S, Miskiewicz K, Poesen K, Lambrechts D, Janssen GM, Fazzi GE, Verstreken P, Haigh J, Schiffers PM, Rohrer H, Van der Linden A, De Mey JG, Carmeliet P. Storkebaum E, et al. Among authors: zacchigna s. Circulation. 2010 Jul 20;122(3):273-81. doi: 10.1161/CIRCULATIONAHA.109.929364. Epub 2010 Jul 6. Circulation. 2010. PMID: 20606119 Free article.
TRAIL shows potential cardioprotective activity.
Toffoli B, Bernardi S, Candido R, Zacchigna S, Fabris B, Secchiero P. Toffoli B, et al. Among authors: zacchigna s. Invest New Drugs. 2012 Jun;30(3):1257-60. doi: 10.1007/s10637-010-9627-8. Epub 2011 Jan 4. Invest New Drugs. 2012. PMID: 21197620
Short term effects of doxycycline on matrix metalloproteinases 2 and 9.
Fiotti N, Altamura N, Moretti M, Wassermann S, Zacchigna S, Farra R, Dapas B, Consoloni L, Giacca M, Grassi G, Giansante C. Fiotti N, et al. Among authors: zacchigna s. Cardiovasc Drugs Ther. 2009 Apr;23(2):153-9. doi: 10.1007/s10557-008-6150-7. Epub 2008 Dec 4. Cardiovasc Drugs Ther. 2009. PMID: 19052856 Clinical Trial.
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