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Unique pharmacodynamic properties and low abuse liability of the μ-opioid receptor ligand (S)-methadone.
Michaelides M, Levinstein M, De Oliveira P, Casajuana-Martin N, Quiroz C, Budinich R, Rais R, Rea W, Ventriglia E, Llopart N, Casadó-Anguera V, Moreno E, Walther D, Glatfelter G, Weinshenker D, Zarate C, Casado V, Baumann M, Pardo L, Ferre S. Michaelides M, et al. Res Sq [Preprint]. 2023 Mar 23:rs.3.rs-2644719. doi: 10.21203/rs.3.rs-2644719/v1. Res Sq. 2023. PMID: 36993715 Free PMC article. Updated. Preprint.
Pharmacological targeting of G protein-coupled receptor heteromers.
Moreno E, Casajuana-Martin N, Coyle M, Campos BC, Galaj E, Del Torrent CL, Seyedian A, Rea W, Cai NS, Bonifazi A, Florán B, Xi ZX, Guitart X, Casadó V, Newman AH, Bishop C, Pardo L, Ferré S. Moreno E, et al. Pharmacol Res. 2022 Nov;185:106476. doi: 10.1016/j.phrs.2022.106476. Epub 2022 Sep 28. Pharmacol Res. 2022. PMID: 36182040 Free PMC article.
Preferential Gs protein coupling of the galanin Gal1 receptor in the µ-opioid-Gal1 receptor heterotetramer.
De Oliveira PA, Moreno E, Casajuana-Martin N, Casadó-Anguera V, Cai NS, Camacho-Hernandez GA, Zhu H, Bonifazi A, Hall MD, Weinshenker D, Newman AH, Logothetis DE, Casadó V, Plant LD, Pardo L, Ferré S. De Oliveira PA, et al. Pharmacol Res. 2022 Aug;182:106322. doi: 10.1016/j.phrs.2022.106322. Epub 2022 Jun 22. Pharmacol Res. 2022. PMID: 35750299 Free PMC article.
Heteromerization between α2A adrenoceptors and different polymorphic variants of the dopamine D4 receptor determines pharmacological and functional differences. Implications for impulsive-control disorders.
Casadó-Anguera V, Moreno E, Sánchez-Soto M, Cai NS, Bonaventura J, Homar-Ruano P, Rubinstein M, Cortés A, Canela EI, Ferré S, Casadó V. Casadó-Anguera V, et al. Pharmacol Res. 2021 Aug;170:105745. doi: 10.1016/j.phrs.2021.105745. Epub 2021 Jun 26. Pharmacol Res. 2021. PMID: 34182128 Free PMC article.