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An inactivated multivalent influenza A virus vaccine is broadly protective in mice and ferrets.
Park J, Fong Legaspi SL, Schwartzman LM, Gygli SM, Sheng ZM, Freeman AD, Matthews LM, Xiao Y, Ramuta MD, Batchenkova NA, Qi L, Rosas LA, Williams SL, Scherler K, Gouzoulis M, Bellayr I, Morens DM, Walters KA, Memoli MJ, Kash JC, Taubenberger JK. Park J, et al. Sci Transl Med. 2022 Jul 13;14(653):eabo2167. doi: 10.1126/scitranslmed.abo2167. Epub 2022 Jul 13. Sci Transl Med. 2022. PMID: 35857640 Free PMC article.
Establishment of a Pig Influenza Challenge Model for Evaluation of Monoclonal Antibody Delivery Platforms.
McNee A, Smith TRF, Holzer B, Clark B, Bessell E, Guibinga G, Brown H, Schultheis K, Fisher P, Ramos S, Nunez A, Bernard M, Graham S, Martini V, Chrun T, Xiao Y, Kash JC, Taubenberger JK, Elliott S, Patel A, Beverley P, Rijal P, Weiner DB, Townsend A, Broderick KE, Tchilian E. McNee A, et al. J Immunol. 2020 Aug 1;205(3):648-660. doi: 10.4049/jimmunol.2000429. Epub 2020 Jun 26. J Immunol. 2020. PMID: 32591390 Free PMC article.
Differential Effects of Influenza Virus NA, HA Head, and HA Stalk Antibodies on Peripheral Blood Leukocyte Gene Expression during Human Infection.
Walters KA, Zhu R, Welge M, Scherler K, Park JK, Rahil Z, Wang H, Auvil L, Bushell C, Lee MY, Baxter D, Bristol T, Rosas LA, Cervantes-Medina A, Czajkowski L, Han A, Memoli MJ, Taubenberger JK, Kash JC. Walters KA, et al. mBio. 2019 May 14;10(3):e00760-19. doi: 10.1128/mBio.00760-19. mBio. 2019. PMID: 31088926 Free PMC article.
Treatment with the reactive oxygen species scavenger EUK-207 reduces lung damage and increases survival during 1918 influenza virus infection in mice.
Kash JC, Xiao Y, Davis AS, Walters KA, Chertow DS, Easterbrook JD, Dunfee RL, Sandouk A, Jagger BW, Schwartzman LM, Kuestner RE, Wehr NB, Huffman K, Rosenthal RA, Ozinsky A, Levine RL, Doctrow SR, Taubenberger JK. Kash JC, et al. Free Radic Biol Med. 2014 Feb;67:235-47. doi: 10.1016/j.freeradbiomed.2013.10.014. Epub 2013 Oct 17. Free Radic Biol Med. 2014. PMID: 24140866 Free PMC article.