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Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity.
Zhang B, Sun J, Yuan Y, Ji D, Sun Y, Liu Y, Li S, Zhu X, Wu X, Hu J, Xie Q, Wu L, Liu L, Cheng B, Zhang Y, Jiang L, Zhao L, Yu F, Song W, Wang M, Xu Y, Ma S, Fei Y, Zhang L, Zhou D, Zhang X. Zhang B, et al. Among authors: yuan y. Signal Transduct Target Ther. 2023 Jan 23;8(1):28. doi: 10.1038/s41392-022-01208-3. Signal Transduct Target Ther. 2023. PMID: 36690610 Free PMC article.
Site-specific PEGylation of interleukin-2 enhances immunosuppression via the sustained activation of regulatory T cells.
Zhang B, Sun J, Wang Y, Ji D, Yuan Y, Li S, Sun Y, Hou Y, Li P, Zhao L, Yu F, Ma W, Cheng B, Wu L, Hu J, Wang M, Song W, Li X, Li H, Fei Y, Chen H, Zhang L, Tsokos GC, Zhou D, Zhang X. Zhang B, et al. Among authors: yuan y. Nat Biomed Eng. 2021 Nov;5(11):1288-1305. doi: 10.1038/s41551-021-00797-8. Epub 2021 Sep 27. Nat Biomed Eng. 2021. PMID: 34580438
Therapeutic potential of interleukin-2 in autoimmune diseases.
Yuan Y, Kolios AGA, Liu Y, Zhang B, Li H, Tsokos GC, Zhang X. Yuan Y, et al. Trends Mol Med. 2022 Jul;28(7):596-612. doi: 10.1016/j.molmed.2022.04.010. Epub 2022 May 24. Trends Mol Med. 2022. PMID: 35624009 Review.
CARs: a new approach for the treatment of autoimmune diseases.
Sun Y, Yuan Y, Zhang B, Zhang X. Sun Y, et al. Among authors: yuan y. Sci China Life Sci. 2023 Apr;66(4):711-728. doi: 10.1007/s11427-022-2212-5. Epub 2022 Nov 4. Sci China Life Sci. 2023. PMID: 36346550 Free PMC article. Review.
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