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SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma.
Choe JH, Watchmaker PB, Simic MS, Gilbert RD, Li AW, Krasnow NA, Downey KM, Yu W, Carrera DA, Celli A, Cho J, Briones JD, Duecker JM, Goretsky YE, Dannenfelser R, Cardarelli L, Troyanskaya O, Sidhu SS, Roybal KT, Okada H, Lim WA. Choe JH, et al. Among authors: yu w. Sci Transl Med. 2021 Apr 28;13(591):eabe7378. doi: 10.1126/scitranslmed.abe7378. Sci Transl Med. 2021. PMID: 33910979 Free PMC article.
T cell circuits that sense antigen density with an ultrasensitive threshold.
Hernandez-Lopez RA, Yu W, Cabral KA, Creasey OA, Lopez Pazmino MDP, Tonai Y, De Guzman A, Mäkelä A, Saksela K, Gartner ZJ, Lim WA. Hernandez-Lopez RA, et al. Among authors: yu w. Science. 2021 Mar 12;371(6534):1166-1171. doi: 10.1126/science.abc1855. Epub 2021 Feb 25. Science. 2021. PMID: 33632893 Free PMC article.
Synthetic cytokine circuits that drive T cells into immune-excluded tumors.
Allen GM, Frankel NW, Reddy NR, Bhargava HK, Yoshida MA, Stark SR, Purl M, Lee J, Yee JL, Yu W, Li AW, Garcia KC, El-Samad H, Roybal KT, Spitzer MH, Lim WA. Allen GM, et al. Among authors: yu w. Science. 2022 Dec 16;378(6625):eaba1624. doi: 10.1126/science.aba1624. Epub 2022 Dec 16. Science. 2022. PMID: 36520915 Free PMC article.
Beta1-integrin orients epithelial polarity via Rac1 and laminin.
Yu W, Datta A, Leroy P, O'Brien LE, Mak G, Jou TS, Matlin KS, Mostov KE, Zegers MM. Yu W, et al. Mol Biol Cell. 2005 Feb;16(2):433-45. doi: 10.1091/mbc.e04-05-0435. Epub 2004 Dec 1. Mol Biol Cell. 2005. PMID: 15574881 Free PMC article.
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