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A novel N-ethyl-N-nitrosourea-induced mutation in phospholipase Cγ2 causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model.
Abe K, Fuchs H, Boersma A, Hans W, Yu P, Kalaydjiev S, Klaften M, Adler T, Calzada-Wack J, Mossbrugger I, Rathkolb B, Rozman J, Prehn C, Maraslioglu M, Kametani Y, Shimada S, Adamski J, Busch DH, Esposito I, Klingenspor M, Wolf E, Wurst W, Gailus-Durner V, Katan M, Marschall S, Soewarto D, Wagner S, de Angelis MH. Abe K, et al. Among authors: yu p. Arthritis Rheum. 2011 May;63(5):1301-11. doi: 10.1002/art.30280. Arthritis Rheum. 2011. PMID: 21305534 Free article.
Characterization of phospholipase C gamma enzymes with gain-of-function mutations.
Everett KL, Bunney TD, Yoon Y, Rodrigues-Lima F, Harris R, Driscoll PC, Abe K, Fuchs H, de Angelis MH, Yu P, Cho W, Katan M. Everett KL, et al. Among authors: yu p. J Biol Chem. 2009 Aug 21;284(34):23083-93. doi: 10.1074/jbc.M109.019265. Epub 2009 Jun 16. J Biol Chem. 2009. PMID: 19531496 Free PMC article.
Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry.
Yu P, Constien R, Dear N, Katan M, Hanke P, Bunney TD, Kunder S, Quintanilla-Martinez L, Huffstadt U, Schröder A, Jones NP, Peters T, Fuchs H, de Angelis MH, Nehls M, Grosse J, Wabnitz P, Meyer TP, Yasuda K, Schiemann M, Schneider-Fresenius C, Jagla W, Russ A, Popp A, Josephs M, Marquardt A, Laufs J, Schmittwolf C, Wagner H, Pfeffer K, Mudde GC. Yu P, et al. Immunity. 2005 Apr;22(4):451-65. doi: 10.1016/j.immuni.2005.01.018. Immunity. 2005. PMID: 15845450 Free article.
Tumor suppressor role of phospholipase C epsilon in Ras-triggered cancers.
Martins M, McCarthy A, Baxendale R, Guichard S, Magno L, Kessaris N, El-Bahrawy M, Yu P, Katan M. Martins M, et al. Among authors: yu p. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4239-44. doi: 10.1073/pnas.1311500111. Epub 2014 Mar 3. Proc Natl Acad Sci U S A. 2014. PMID: 24591640 Free PMC article.
Mutation of mouse Mayp/Pstpip2 causes a macrophage autoinflammatory disease.
Grosse J, Chitu V, Marquardt A, Hanke P, Schmittwolf C, Zeitlmann L, Schropp P, Barth B, Yu P, Paffenholz R, Stumm G, Nehls M, Stanley ER. Grosse J, et al. Among authors: yu p. Blood. 2006 Apr 15;107(8):3350-8. doi: 10.1182/blood-2005-09-3556. Epub 2006 Jan 5. Blood. 2006. PMID: 16397132 Free PMC article.
An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice.
Grosse J, Braun A, Varga-Szabo D, Beyersdorf N, Schneider B, Zeitlmann L, Hanke P, Schropp P, Mühlstedt S, Zorn C, Huber M, Schmittwolf C, Jagla W, Yu P, Kerkau T, Schulze H, Nehls M, Nieswandt B. Grosse J, et al. Among authors: yu p. J Clin Invest. 2007 Nov;117(11):3540-50. doi: 10.1172/JCI32312. J Clin Invest. 2007. PMID: 17965774 Free PMC article.
7,968 results