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Page 1
Optimization of substituted imidazobenzodiazepines as novel asthma treatments.
Jahan R, Stephen MR, Forkuo GS, Kodali R, Guthrie ML, Nieman AN, Yuan NY, Zahn NM, Poe MM, Li G, Yu OB, Yocum GT, Emala CW, Stafford DC, Cook JM, Arnold LA. Jahan R, et al. Among authors: yu ob. Eur J Med Chem. 2017 Jan 27;126:550-560. doi: 10.1016/j.ejmech.2016.11.045. Epub 2016 Nov 24. Eur J Med Chem. 2017. PMID: 27915170 Free PMC article.
Development of GABAA Receptor Subtype-Selective Imidazobenzodiazepines as Novel Asthma Treatments.
Forkuo GS, Guthrie ML, Yuan NY, Nieman AN, Kodali R, Jahan R, Stephen MR, Yocum GT, Treven M, Poe MM, Li G, Yu OB, Hartzler BD, Zahn NM, Ernst M, Emala CW, Stafford DC, Cook JM, Arnold LA. Forkuo GS, et al. Among authors: yu ob. Mol Pharm. 2016 Jun 6;13(6):2026-38. doi: 10.1021/acs.molpharmaceut.6b00159. Epub 2016 May 10. Mol Pharm. 2016. PMID: 27120014 Free PMC article.
Alleviation of Multiple Asthmatic Pathologic Features with Orally Available and Subtype Selective GABAA Receptor Modulators.
Forkuo GS, Nieman AN, Yuan NY, Kodali R, Yu OB, Zahn NM, Jahan R, Li G, Stephen MR, Guthrie ML, Poe MM, Hartzler BD, Harris TW, Yocum GT, Emala CW, Steeber DA, Stafford DC, Cook JM, Arnold LA. Forkuo GS, et al. Among authors: yu ob. Mol Pharm. 2017 Jun 5;14(6):2088-2098. doi: 10.1021/acs.molpharmaceut.7b00183. Epub 2017 May 1. Mol Pharm. 2017. PMID: 28440659 Free PMC article.
A Novel Orally Available Asthma Drug Candidate That Reduces Smooth Muscle Constriction and Inflammation by Targeting GABAA Receptors in the Lung.
Forkuo GS, Nieman AN, Kodali R, Zahn NM, Li G, Rashid Roni MS, Stephen MR, Harris TW, Jahan R, Guthrie ML, Yu OB, Fisher JL, Yocum GT, Emala CW, Steeber DA, Stafford DC, Cook JM, Arnold LA. Forkuo GS, et al. Among authors: yu ob. Mol Pharm. 2018 May 7;15(5):1766-1777. doi: 10.1021/acs.molpharmaceut.7b01013. Epub 2018 Apr 2. Mol Pharm. 2018. PMID: 29578347 Free PMC article.
Calcitroic Acid-A Review.
Yu OB, Arnold LA. Yu OB, et al. ACS Chem Biol. 2016 Oct 21;11(10):2665-2672. doi: 10.1021/acschembio.6b00569. Epub 2016 Sep 6. ACS Chem Biol. 2016. PMID: 27574921 Free PMC article. Review.
Synthesis and biological evaluation of calcioic acid.
Yu OB, Mutchie TR, Di Milo ES, Arnold LA. Yu OB, et al. Steroids. 2020 Feb;154:108536. doi: 10.1016/j.steroids.2019.108536. Epub 2019 Nov 6. Steroids. 2020. PMID: 31704333 Free PMC article.
Biological evaluation and synthesis of calcitroic acid.
Yu OB, Webb DA, Di Milo ES, Mutchie TR, Teske KA, Chen T, Lin W, Peluso-Iltis C, Rochel N, Helmstädter M, Merk D, Arnold LA. Yu OB, et al. Bioorg Chem. 2021 Nov;116:105310. doi: 10.1016/j.bioorg.2021.105310. Epub 2021 Aug 28. Bioorg Chem. 2021. PMID: 34482171 Free PMC article. Review.
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