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Lipoprotein(a) induces caspase-1 activation and IL-1 signaling in human macrophages.
Lorey MB, Youssef A, Äikäs L, Borrelli M, Hermansson M, Assini JM, Kemppainen A, Ruhanen H, Ruuth M, Matikainen S, Kovanen PT, Käkelä R, Boffa MB, Koschinsky ML, Öörni K. Lorey MB, et al. Among authors: youssef a. Front Cardiovasc Med. 2023 May 24;10:1130162. doi: 10.3389/fcvm.2023.1130162. eCollection 2023. Front Cardiovasc Med. 2023. PMID: 37293282 Free PMC article.
New Frontiers in Lp(a)-Targeted Therapies.
Borrelli MJ, Youssef A, Boffa MB, Koschinsky ML. Borrelli MJ, et al. Among authors: youssef a. Trends Pharmacol Sci. 2019 Mar;40(3):212-225. doi: 10.1016/j.tips.2019.01.004. Epub 2019 Feb 4. Trends Pharmacol Sci. 2019. PMID: 30732864 Review.
High levels of lipoprotein(a) in transgenic mice exacerbate atherosclerosis and promote vulnerable plaque features in a sex-specific manner.
Assini JM, Clark JR, Youssef A, Xing C, Doerfler AM, Park SH, Saxena L, Yaseen AB, Børen J, Gros R, Bao G, Lagor WR, Boffa MB, Koschinsky ML. Assini JM, et al. Among authors: youssef a. Atherosclerosis. 2023 Nov;384:117150. doi: 10.1016/j.atherosclerosis.2023.05.019. Epub 2023 May 30. Atherosclerosis. 2023. PMID: 37290980
LPA disruption with AAV-CRISPR potently lowers plasma apo(a) in transgenic mouse model: A proof-of-concept study.
Doerfler AM, Park SH, Assini JM, Youssef A, Saxena L, Yaseen AB, De Giorgi M, Chuecos M, Hurley AE, Li A, Marcovina SM, Bao G, Boffa MB, Koschinsky ML, Lagor WR. Doerfler AM, et al. Among authors: youssef a. Mol Ther Methods Clin Dev. 2022 Oct 13;27:337-351. doi: 10.1016/j.omtm.2022.10.009. eCollection 2022 Dec 8. Mol Ther Methods Clin Dev. 2022. PMID: 36381302 Free PMC article.
1,247 results