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Senolytics reduce coronavirus-related mortality in old mice.
Camell CD, Yousefzadeh MJ, Zhu Y, Prata LGPL, Huggins MA, Pierson M, Zhang L, O'Kelly RD, Pirtskhalava T, Xun P, Ejima K, Xue A, Tripathi U, Espindola-Netto JM, Giorgadze N, Atkinson EJ, Inman CL, Johnson KO, Cholensky SH, Carlson TW, LeBrasseur NK, Khosla S, O'Sullivan MG, Allison DB, Jameson SC, Meves A, Li M, Prakash YS, Chiarella SE, Hamilton SE, Tchkonia T, Niedernhofer LJ, Kirkland JL, Robbins PD. Camell CD, et al. Among authors: yousefzadeh mj. Science. 2021 Jul 16;373(6552):eabe4832. doi: 10.1126/science.abe4832. Epub 2021 Jun 8. Science. 2021. PMID: 34103349 Free PMC article.
Oxidation Products of 5-Methylcytosine are Decreased in Senescent Cells and Tissues of Progeroid Mice.
Zarakowska E, Czerwinska J, Tupalska A, Yousefzadeh MJ, Gregg SQ, Croix CMS, Niedernhofer LJ, Foksinski M, Gackowski D, Szpila A, Starczak M, Tudek B, Olinski R. Zarakowska E, et al. Among authors: yousefzadeh mj. J Gerontol A Biol Sci Med Sci. 2018 Jul 9;73(8):1003-1009. doi: 10.1093/gerona/gly012. J Gerontol A Biol Sci Med Sci. 2018. PMID: 29415265 Free PMC article.
Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging.
Robinson AR, Yousefzadeh MJ, Rozgaja TA, Wang J, Li X, Tilstra JS, Feldman CH, Gregg SQ, Johnson CH, Skoda EM, Frantz MC, Bell-Temin H, Pope-Varsalona H, Gurkar AU, Nasto LA, Robinson RAS, Fuhrmann-Stroissnigg H, Czerwinska J, McGowan SJ, Cantu-Medellin N, Harris JB, Maniar S, Ross MA, Trussoni CE, LaRusso NF, Cifuentes-Pagano E, Pagano PJ, Tudek B, Vo NV, Rigatti LH, Opresko PL, Stolz DB, Watkins SC, Burd CE, Croix CMS, Siuzdak G, Yates NA, Robbins PD, Wang Y, Wipf P, Kelley EE, Niedernhofer LJ. Robinson AR, et al. Among authors: yousefzadeh mj. Redox Biol. 2018 Jul;17:259-273. doi: 10.1016/j.redox.2018.04.007. Epub 2018 Apr 13. Redox Biol. 2018. PMID: 29747066 Free PMC article.
Fisetin is a senotherapeutic that extends health and lifespan.
Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, Ling YY, Melos KI, Pirtskhalava T, Inman CL, McGuckian C, Wade EA, Kato JI, Grassi D, Wentworth M, Burd CE, Arriaga EA, Ladiges WL, Tchkonia T, Kirkland JL, Robbins PD, Niedernhofer LJ. Yousefzadeh MJ, et al. EBioMedicine. 2018 Oct;36:18-28. doi: 10.1016/j.ebiom.2018.09.015. Epub 2018 Sep 29. EBioMedicine. 2018. PMID: 30279143 Free PMC article.
Mouse Models of Accelerated Cellular Senescence.
Yousefzadeh MJ, Melos KI, Angelini L, Burd CE, Robbins PD, Niedernhofer LJ. Yousefzadeh MJ, et al. Methods Mol Biol. 2019;1896:203-230. doi: 10.1007/978-1-4939-8931-7_17. Methods Mol Biol. 2019. PMID: 30474850 Free PMC article.
Measuring biological age in mice using differential mass spectrometry.
Bell-Temin H, Yousefzadeh MJ, Bondarenko A, Quarles E, Jones-Laughner J, Robbins PD, Ladiges W, Niedernhofer LJ, Yates NA. Bell-Temin H, et al. Among authors: yousefzadeh mj. Aging (Albany NY). 2019 Feb 11;11(3):1045-1061. doi: 10.18632/aging.101810. Aging (Albany NY). 2019. PMID: 30745468 Free PMC article.
Signal Transduction, Ageing and Disease.
Zhang L, Yousefzadeh MJ, Suh Y, Niedernhofer LJ, Robbins PD. Zhang L, et al. Among authors: yousefzadeh mj. Subcell Biochem. 2019;91:227-247. doi: 10.1007/978-981-13-3681-2_9. Subcell Biochem. 2019. PMID: 30888655 Review.
Adenoviral gene transfer of a single-chain IL-23 induces psoriatic arthritis-like symptoms in NOD mice.
Flores RR, Carbo L, Kim E, Van Meter M, De Padilla CML, Zhao J, Colangelo D, Yousefzadeh MJ, Angelini LA, Zhang L, Pola E, Vo N, Evans CH, Gambotto A, Niedernhofer LJ, Robbins PD. Flores RR, et al. Among authors: yousefzadeh mj. FASEB J. 2019 Aug;33(8):9505-9515. doi: 10.1096/fj.201900420R. Epub 2019 Jun 6. FASEB J. 2019. PMID: 31170010 Free PMC article.
39 results