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Certain heterozygous variants in the kinase domain of the serine/threonine kinase NEK8 can cause an autosomal dominant form of polycystic kidney disease.
Claus LR, Chen C, Stallworth J, Turner JL, Slaats GG, Hawks AL, Mabillard H, Senum SR, Srikanth S, Flanagan-Steet H, Louie RJ, Silver J, Lerner-Ellis J, Morel C, Mighton C, Sleutels F, van Slegtenhorst M, van Ham T, Brooks AS, Dorresteijn EM, Barakat TS, Dahan K, Demoulin N, Goffin EJ, Olinger E; Genomics England Research Consortium; Larsen M, Hertz JM, Lilien MR, Obeidová L, Seeman T, Stone HK, Kerecuk L, Gurgu M, Yousef Yengej FA, Ammerlaan CME, Rookmaaker MB, Hanna C, Rogers RC, Duran K, Peters E, Sayer JA, van Haaften G, Harris PC, Ling K, Mason JM, van Eerde AM, Steet R. Claus LR, et al. Among authors: yousef yengej fa. Kidney Int. 2023 Nov;104(5):995-1007. doi: 10.1016/j.kint.2023.07.021. Epub 2023 Aug 19. Kidney Int. 2023. PMID: 37598857
Kidney Organoids and Tubuloids.
Yousef Yengej FA, Jansen J, Rookmaaker MB, Verhaar MC, Clevers H. Yousef Yengej FA, et al. Cells. 2020 May 26;9(6):1326. doi: 10.3390/cells9061326. Cells. 2020. PMID: 32466429 Free PMC article. Review.
Culture and analysis of kidney tubuloids and perfused tubuloid cells-on-a-chip.
Gijzen L, Yousef Yengej FA, Schutgens F, Vormann MK, Ammerlaan CME, Nicolas A, Kurek D, Vulto P, Rookmaaker MB, Lanz HL, Verhaar MC, Clevers H. Gijzen L, et al. Among authors: yousef yengej fa. Nat Protoc. 2021 Apr;16(4):2023-2050. doi: 10.1038/s41596-020-00479-w. Epub 2021 Mar 5. Nat Protoc. 2021. PMID: 33674788
Cysteamine-bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis.
Jamalpoor A, van Gelder CA, Yousef Yengej FA, Zaal EA, Berlingerio SP, Veys KR, Pou Casellas C, Voskuil K, Essa K, Ammerlaan CM, Rega LR, van der Welle RE, Lilien MR, Rookmaaker MB, Clevers H, Klumperman J, Levtchenko E, Berkers CR, Verhaar MC, Altelaar M, Masereeuw R, Janssen MJ. Jamalpoor A, et al. Among authors: yousef yengej fa. EMBO Mol Med. 2021 Jul 7;13(7):e13067. doi: 10.15252/emmm.202013067. Epub 2021 Jun 24. EMBO Mol Med. 2021. PMID: 34165243 Free PMC article.
Differentiated mouse kidney tubuloids as a novel in vitro model to study collecting duct physiology.
Olde Hanhof CJA, Dilmen E, Yousef Yengej FA, Latta F, Ammerlaan CME, Schreurs J, Hooijmaijers L, Jansen J, Rookmaaker MB, Orhon I, Verhaar MC, Hoenderop JG. Olde Hanhof CJA, et al. Among authors: yousef yengej fa. Front Cell Dev Biol. 2023 Jan 25;11:1086823. doi: 10.3389/fcell.2023.1086823. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 36760360 Free PMC article.
Differentiation and CRISPR-Cas9-mediated genetic engineering of human intestinal organoids.
Martinez-Silgado A, Yousef Yengej FA, Puschhof J, Geurts V, Boot C, Geurts MH, Rookmaaker MB, Verhaar MC, Beumer J, Clevers H. Martinez-Silgado A, et al. Among authors: yousef yengej fa. STAR Protoc. 2022 Aug 18;3(3):101639. doi: 10.1016/j.xpro.2022.101639. eCollection 2022 Sep 16. STAR Protoc. 2022. PMID: 36042877 Free PMC article.
15 results