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The design and synthesis of novel, phosphonate-containing transient receptor potential melastatin 8 (TRPM8) antagonists.
Matthews JM, Qin N, Colburn RW, Dax SL, Hawkins M, McNally JJ, Reany L, Youngman MA, Baker J, Hutchinson T, Liu Y, Lubin ML, Neeper M, Brandt MR, Stone DJ, Flores CM. Matthews JM, et al. Among authors: youngman ma. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2922-6. doi: 10.1016/j.bmcl.2012.02.060. Epub 2012 Feb 27. Bioorg Med Chem Lett. 2012. PMID: 22421018
Heteroaryl beta-tetralin ureas as novel antagonists of human TRPV1.
Jetter MC, Youngman MA, McNally JJ, McDonnell ME, Zhang SP, Dubin AE, Nasser N, Codd EE, Flores CM, Dax SL. Jetter MC, et al. Among authors: youngman ma. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6160-3. doi: 10.1016/j.bmcl.2007.09.036. Epub 2007 Sep 12. Bioorg Med Chem Lett. 2007. PMID: 17892935
Arylglycine derivatives as potent transient receptor potential melastatin 8 (TRPM8) antagonists.
Zhu B, Xia M, Xu X, Ludovici DW, Tennakoon M, Youngman MA, Matthews JM, Dax SL, Colburn RW, Qin N, Hutchinson TL, Lubin ML, Brandt MR, Stone DJ, Flores CM, Macielag MJ. Zhu B, et al. Among authors: youngman ma. Bioorg Med Chem Lett. 2013 Apr 1;23(7):2234-7. doi: 10.1016/j.bmcl.2013.01.062. Epub 2013 Feb 4. Bioorg Med Chem Lett. 2013. PMID: 23411075
Novel non-peptidic neuropeptide Y Y2 receptor antagonists.
Jablonowski JA, Chai W, Li X, Rudolph DA, Murray WV, Youngman MA, Dax SL, Nepomuceno D, Bonaventure P, Lovenberg TW, Carruthers NI. Jablonowski JA, et al. Among authors: youngman ma. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1239-42. doi: 10.1016/j.bmcl.2003.12.057. Bioorg Med Chem Lett. 2004. PMID: 14980673
Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep).
Parsons WH, Calvo RR, Cheung W, Lee YK, Patel S, Liu J, Youngman MA, Dax SL, Stone D, Qin N, Hutchinson T, Lubin ML, Zhang SP, Finley M, Liu Y, Brandt MR, Flores CM, Player MR. Parsons WH, et al. Among authors: youngman ma. J Med Chem. 2015 May 14;58(9):3859-74. doi: 10.1021/acs.jmedchem.5b00132. Epub 2015 Apr 15. J Med Chem. 2015. PMID: 25850459
16 results