Young PR - Search Results

1

Micro-fusion inhibition tests: quantifying antibody neutralization of virus-mediated cell-cell fusion.

Thakur N, Conceicao C, Isaacs A, Human S, Modhiran N, McLean RK, Pedrera M, Tan TK, Rijal P, Townsend A, Taylor G, Young PR, Watterson D, Chappell KJ, Graham SP, Bailey D. Thakur N, et al. Among authors: young pr. J Gen Virol. 2021 Jan;102(1):jgv001506. doi: 10.1099/jgv.0.001506. Epub 2020 Oct 15. J Gen Virol. 2021. PMID: 33054904 Free PMC article.

2

Structural characterization of respiratory syncytial virus fusion inhibitor escape mutants: homology model of the F protein and a syncytium formation assay.

Morton CJ, Cameron R, Lawrence LJ, Lin B, Lowe M, Luttick A, Mason A, McKimm-Breschkin J, Parker MW, Ryan J, Smout M, Sullivan J, Tucker SP, Young PR. Morton CJ, et al. Among authors: young pr. Virology. 2003 Jul 5;311(2):275-88. doi: 10.1016/s0042-6822(03)00115-6. Virology. 2003. PMID: 12842618 Free article.

3

Enzymatic characterization and homology model of a catalytically active recombinant West Nile virus NS3 protease.

Nall TA, Chappell KJ, Stoermer MJ, Fang NX, Tyndall JD, Young PR, Fairlie DP. Nall TA, et al. Among authors: young pr. J Biol Chem. 2004 Nov 19;279(47):48535-42. doi: 10.1074/jbc.M406810200. Epub 2004 Aug 18. J Biol Chem. 2004. PMID: 15322074 Free article.

4

Site-directed mutagenesis and kinetic studies of the West Nile Virus NS3 protease identify key enzyme-substrate interactions.

Chappell KJ, Nall TA, Stoermer MJ, Fang NX, Tyndall JD, Fairlie DP, Young PR. Chappell KJ, et al. Among authors: young pr. J Biol Chem. 2005 Jan 28;280(4):2896-903. doi: 10.1074/jbc.M409931200. Epub 2004 Oct 19. J Biol Chem. 2005. PMID: 15494419 Free article.

5

The Role of histidine residues in low-pH-mediated viral membrane fusion.

Kampmann T, Mueller DS, Mark AE, Young PR, Kobe B. Kampmann T, et al. Among authors: young pr. Structure. 2006 Oct;14(10):1481-7. doi: 10.1016/j.str.2006.07.011. Structure. 2006. PMID: 17027497 Free article. Review.

6

Insights to substrate binding and processing by West Nile Virus NS3 protease through combined modeling, protease mutagenesis, and kinetic studies.

Chappell KJ, Stoermer MJ, Fairlie DP, Young PR. Chappell KJ, et al. Among authors: young pr. J Biol Chem. 2006 Dec 15;281(50):38448-58. doi: 10.1074/jbc.M607641200. Epub 2006 Oct 19. J Biol Chem. 2006. PMID: 17052977 Free article.

7

Generation and characterization of proteolytically active and highly stable truncated and full-length recombinant West Nile virus NS3.

Chappell KJ, Stoermer MJ, Fairlie DP, Young PR. Chappell KJ, et al. Among authors: young pr. Protein Expr Purif. 2007 May;53(1):87-96. doi: 10.1016/j.pep.2006.10.022. Epub 2006 Nov 7. Protein Expr Purif. 2007. PMID: 17174105

8

A dual-purpose synthetic colloidal platform for protease mapping: substrate profiling for Dengue and West Nile virus proteases.

Marcon L, Kozak D, Battersby BJ, Chappell KJ, Fairlie DP, Young P, Trau M. Marcon L, et al. Anal Biochem. 2008 May 1;376(1):151-3. doi: 10.1016/j.ab.2008.01.034. Epub 2008 Feb 2. Anal Biochem. 2008. PMID: 18312847

9

Mutagenesis of the West Nile virus NS2B cofactor domain reveals two regions essential for protease activity.

Chappell KJ, Stoermer MJ, Fairlie DP, Young PR. Chappell KJ, et al. Among authors: young pr. J Gen Virol. 2008 Apr;89(Pt 4):1010-1014. doi: 10.1099/vir.0.83447-0. J Gen Virol. 2008. PMID: 18343843

10

Potent cationic inhibitors of West Nile virus NS2B/NS3 protease with serum stability, cell permeability and antiviral activity.

Stoermer MJ, Chappell KJ, Liebscher S, Jensen CM, Gan CH, Gupta PK, Xu WJ, Young PR, Fairlie DP. Stoermer MJ, et al. Among authors: young pr. J Med Chem. 2008 Sep 25;51(18):5714-21. doi: 10.1021/jm800503y. Epub 2008 Aug 26. J Med Chem. 2008. PMID: 18729351

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