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Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease.
Alysandratos KD, Russo SJ, Petcherski A, Taddeo EP, Acín-Pérez R, Villacorta-Martin C, Jean JC, Mulugeta S, Rodriguez LR, Blum BC, Hekman RM, Hix OT, Minakin K, Vedaie M, Kook S, Tilston-Lunel AM, Varelas X, Wambach JA, Cole FS, Hamvas A, Young LR, Liesa M, Emili A, Guttentag SH, Shirihai OS, Beers MF, Kotton DN. Alysandratos KD, et al. Among authors: young lr. Cell Rep. 2021 Aug 31;36(9):109636. doi: 10.1016/j.celrep.2021.109636. Cell Rep. 2021. PMID: 34469722 Free PMC article.
Impaired Lysosomal Integral Membrane Protein 2-dependent Peroxiredoxin 6 Delivery to Lamellar Bodies Accounts for Altered Alveolar Phospholipid Content in Adaptor Protein-3-deficient pearl Mice.
Kook S, Wang P, Young LR, Schwake M, Saftig P, Weng X, Meng Y, Neculai D, Marks MS, Gonzales L, Beers MF, Guttentag S. Kook S, et al. Among authors: young lr. J Biol Chem. 2016 Apr 15;291(16):8414-27. doi: 10.1074/jbc.M116.720201. Epub 2016 Feb 23. J Biol Chem. 2016. PMID: 26907692 Free PMC article.
Gene-edited MLE-15 Cells as a Model for the Hermansky-Pudlak Syndromes.
Kook S, Qi A, Wang P, Meng S, Gulleman P, Young LR, Guttentag SH. Kook S, et al. Among authors: young lr. Am J Respir Cell Mol Biol. 2018 May;58(5):566-574. doi: 10.1165/rcmb.2017-0324MA. Am J Respir Cell Mol Biol. 2018. PMID: 29190429 Free PMC article.
Successful Establishment of Primary Type II Alveolar Epithelium with 3D Organotypic Coculture.
Sucre JMS, Jetter CS, Loomans H, Williams J, Plosa EJ, Benjamin JT, Young LR, Kropski JA, Calvi CL, Kook S, Wang P, Gleaves L, Eskaros A, Goetzl L, Blackwell TS, Guttentag SH, Zijlstra A. Sucre JMS, et al. Among authors: young lr. Am J Respir Cell Mol Biol. 2018 Aug;59(2):158-166. doi: 10.1165/rcmb.2017-0442MA. Am J Respir Cell Mol Biol. 2018. PMID: 29625013 Free PMC article.
β1 Integrin regulates adult lung alveolar epithelial cell inflammation.
Plosa EJ, Benjamin JT, Sucre JM, Gulleman PM, Gleaves LA, Han W, Kook S, Polosukhin VV, Haake SM, Guttentag SH, Young LR, Pozzi A, Blackwell TS, Zent R. Plosa EJ, et al. Among authors: young lr. JCI Insight. 2020 Jan 30;5(2):e129259. doi: 10.1172/jci.insight.129259. JCI Insight. 2020. PMID: 31873073 Free PMC article.
Neuroendocrine Cell Hyperplasia of Infancy. Clinical Score and Comorbidities.
Liptzin DR, Pickett K, Brinton JT, Agarwal A, Fishman MP, Casey A, Towe CT, Taylor JB, Kurland G, Hagood JS, Wambach J, Srivastava R, Al-Saleh H, Dell SD, Young LR, Deterding RR. Liptzin DR, et al. Among authors: young lr. Ann Am Thorac Soc. 2020 Jun;17(6):724-728. doi: 10.1513/AnnalsATS.201908-617OC. Ann Am Thorac Soc. 2020. PMID: 32109152 Free PMC article.
288 results