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In vitro potency, pharmacokinetic profiles, and pharmacological activity of optimized anti-IL-21R antibodies in a mouse model of lupus.
Vugmeyster Y, Guay H, Szklut P, Qian MD, Jin M, Widom A, Spaulding V, Bennett F, Lowe L, Andreyeva T, Lowe D, Lane S, Thom G, Valge-Archer V, Gill D, Young D, Bloom L. Vugmeyster Y, et al. Among authors: young d. MAbs. 2010 May-Jun;2(3):335-46. doi: 10.4161/mabs.2.3.11850. Epub 2010 May 23. MAbs. 2010. PMID: 20424514 Free PMC article.
Correlation of pharmacodynamic activity, pharmacokinetics, and anti-product antibody responses to anti-IL-21R antibody therapeutics following IV administration to cynomolgus monkeys.
Vugmeyster Y, Allen S, Szklut P, Bree A, Ryan M, Ma M, Spaulding V, Young D, Guay H, Bloom L, Leach MW, O'Toole M, Adkins K. Vugmeyster Y, et al. Among authors: young d. J Transl Med. 2010 Apr 26;8:41. doi: 10.1186/1479-5876-8-41. J Transl Med. 2010. PMID: 20420683 Free PMC article.
IL-21 receptor is critical for the development of memory B cell responses.
Rankin AL, MacLeod H, Keegan S, Andreyeva T, Lowe L, Bloom L, Collins M, Nickerson-Nutter C, Young D, Guay H. Rankin AL, et al. Among authors: young d. J Immunol. 2011 Jan 15;186(2):667-74. doi: 10.4049/jimmunol.0903207. Epub 2010 Dec 17. J Immunol. 2011. PMID: 21169545
IL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Fas(lpr/lpr)/J mice.
Rankin AL, Guay H, Herber D, Bertino SA, Duzanski TA, Carrier Y, Keegan S, Senices M, Stedman N, Ryan M, Bloom L, Medley Q, Collins M, Nickerson-Nutter C, Craft J, Young D, Dunussi-Joannopoulos K. Rankin AL, et al. Among authors: young d. J Immunol. 2012 Feb 15;188(4):1656-67. doi: 10.4049/jimmunol.1003871. Epub 2012 Jan 9. J Immunol. 2012. PMID: 22231702 Free PMC article.
Assessing agonistic potential of a candidate therapeutic anti-IL21R antibody.
Guo Y, Hill AA, Ramsey RC, Immermann FW, Corcoran C, Young D, Lavallie ER, Ryan M, Bechard T, Pfeifer R, Warner G, Bologna M, Bloom L, O'Toole M. Guo Y, et al. Among authors: young d. J Transl Med. 2010 May 26;8:50. doi: 10.1186/1479-5876-8-50. J Transl Med. 2010. PMID: 20504348 Free PMC article.
IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity.
Kasaian MT, Whitters MJ, Carter LL, Lowe LD, Jussif JM, Deng B, Johnson KA, Witek JS, Senices M, Konz RF, Wurster AL, Donaldson DD, Collins M, Young DA, Grusby MJ. Kasaian MT, et al. Among authors: young da. Immunity. 2002 Apr;16(4):559-69. doi: 10.1016/s1074-7613(02)00295-9. Immunity. 2002. PMID: 11970879 Free article.
5,318 results