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Page 1
Stromal Reprogramming through Dual PDGFRα/β Blockade Boosts the Efficacy of Anti-PD-1 Immunotherapy in Fibrotic Tumors.
Akiyama T, Yasuda T, Uchihara T, Yasuda-Yoshihara N, Tan BJY, Yonemura A, Semba T, Yamasaki J, Komohara Y, Ohnishi K, Wei F, Fu L, Zhang J, Kitamura F, Yamashita K, Eto K, Iwagami S, Tsukamoto H, Umemoto T, Masuda M, Nagano O, Satou Y, Saya H, Tan P, Baba H, Ishimoto T. Akiyama T, et al. Among authors: yonemura a. Cancer Res. 2023 Mar 2;83(5):753-770. doi: 10.1158/0008-5472.CAN-22-1890. Cancer Res. 2023. PMID: 36543251
Inhibition of 15-PGDH causes Kras-driven tumor expansion through prostaglandin E2-ALDH1 signaling in the pancreas.
Arima K, Ohmuraya M, Miyake K, Koiwa M, Uchihara T, Izumi D, Gao F, Yonemura A, Bu L, Okabe H, Imai K, Hashimoto D, Baba Y, Chikamoto A, Yamashita YI, Furukawa T, Araki K, Baba H, Ishimoto T. Arima K, et al. Among authors: yonemura a. Oncogene. 2019 Feb;38(8):1211-1224. doi: 10.1038/s41388-018-0510-y. Epub 2018 Sep 24. Oncogene. 2019. PMID: 30250298
Extracellular Vesicles from Cancer-Associated Fibroblasts Containing Annexin A6 Induces FAK-YAP Activation by Stabilizing β1 Integrin, Enhancing Drug Resistance.
Uchihara T, Miyake K, Yonemura A, Komohara Y, Itoyama R, Koiwa M, Yasuda T, Arima K, Harada K, Eto K, Hayashi H, Iwatsuki M, Iwagami S, Baba Y, Yoshida N, Yashiro M, Masuda M, Ajani JA, Tan P, Baba H, Ishimoto T. Uchihara T, et al. Among authors: yonemura a. Cancer Res. 2020 Aug 15;80(16):3222-3235. doi: 10.1158/0008-5472.CAN-19-3803. Epub 2020 Jun 30. Cancer Res. 2020. PMID: 32605995
Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination.
Yasuda T, Koiwa M, Yonemura A, Miyake K, Kariya R, Kubota S, Yokomizo-Nakano T, Yasuda-Yoshihara N, Uchihara T, Itoyama R, Bu L, Fu L, Arima K, Izumi D, Iwagami S, Eto K, Iwatsuki M, Baba Y, Yoshida N, Ohguchi H, Okada S, Matsusaki K, Sashida G, Takahashi A, Tan P, Baba H, Ishimoto T. Yasuda T, et al. Among authors: yonemura a. Cell Rep. 2021 Feb 23;34(8):108779. doi: 10.1016/j.celrep.2021.108779. Cell Rep. 2021. PMID: 33626356 Free article.
Metabolic shift to serine biosynthesis through 3-PG accumulation and PHGDH induction promotes tumor growth in pancreatic cancer.
Itoyama R, Yasuda-Yoshihara N, Kitamura F, Yasuda T, Bu L, Yonemura A, Uchihara T, Arima K, Hu X, Jun Z, Okamoto Y, Akiyama T, Yamashita K, Nakao Y, Yusa T, Kitano Y, Higashi T, Miyata T, Imai K, Hayashi H, Yamashita YI, Mikawa T, Kondoh H, Baba H, Ishimoto T. Itoyama R, et al. Among authors: yonemura a. Cancer Lett. 2021 Dec 28;523:29-42. doi: 10.1016/j.canlet.2021.09.007. Epub 2021 Sep 9. Cancer Lett. 2021. PMID: 34508795
Intracellular MUC20 variant 2 maintains mitochondrial calcium homeostasis and enhances drug resistance in gastric cancer.
Fu L, Yonemura A, Yasuda-Yoshihara N, Umemoto T, Zhang J, Yasuda T, Uchihara T, Akiyama T, Kitamura F, Yamashita K, Okamoto Y, Bu L, Wei F, Hu X, Liu Y, Ajani JA, Tan P, Baba H, Ishimoto T. Fu L, et al. Among authors: yonemura a. Gastric Cancer. 2022 May;25(3):542-557. doi: 10.1007/s10120-022-01283-z. Epub 2022 Feb 15. Gastric Cancer. 2022. PMID: 35166958
Tumor microenvironmental 15-PGDH depletion promotes fibrotic tumor formation and angiogenesis in pancreatic cancer.
Bu L, Yonemura A, Yasuda-Yoshihara N, Uchihara T, Ismagulov G, Takasugi S, Yasuda T, Okamoto Y, Kitamura F, Akiyama T, Arima K, Itoyama R, Zhang J, Fu L, Hu X, Wei F, Arima Y, Moroishi T, Nishiyama K, Sheng G, Mukunoki T, Otani J, Baba H, Ishimoto T. Bu L, et al. Among authors: yonemura a. Cancer Sci. 2022 Oct;113(10):3579-3592. doi: 10.1111/cas.15495. Epub 2022 Aug 23. Cancer Sci. 2022. PMID: 35848891 Free PMC article.
IL-1β derived from mixed-polarized macrophages activates fibroblasts and synergistically forms a cancer-promoting microenvironment.
Zhang J, Fu L, Yasuda-Yoshihara N, Yonemura A, Wei F, Bu L, Hu X, Akiyama T, Kitamura F, Yasuda T, Semba T, Uchihara T, Itoyama R, Yamashita K, Eto K, Iwagami S, Yashiro M, Komohara Y, Baba H, Ishimoto T. Zhang J, et al. Among authors: yonemura a. Gastric Cancer. 2023 Mar;26(2):187-202. doi: 10.1007/s10120-022-01352-3. Epub 2022 Dec 13. Gastric Cancer. 2023. PMID: 36513910
A novel tdTomato transgenic mouse model to visualize FAP-positive cancer-associated fibroblasts.
Wei F, Uchihara T, Yonemura A, Yasuda-Yoshihara N, Yasuda T, Semba T, Fukuda M, Akiyama T, Kitamura F, Bu L, Hu X, Fu L, Zhang J, Kariya R, Yamasaki J, Aihara K, Yamashita K, Nagano O, Okada S, Baba H, Ishimoto T. Wei F, et al. Among authors: yonemura a. FEBS J. 2023 May;290(10):2604-2615. doi: 10.1111/febs.16712. Epub 2023 Jan 3. FEBS J. 2023. PMID: 36565059 Free article.
49 results