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Page 1
Discovery of Selective Transforming Growth Factor β Type II Receptor Inhibitors as Antifibrosis Agents.
Miwa S, Yokota M, Ueyama Y, Maeda K, Ogoshi Y, Seki N, Ogawa N, Nishihata J, Nomura A, Adachi T, Kitao Y, Nozawa K, Ishikawa T, Ukaji Y, Shiozaki M. Miwa S, et al. Among authors: yokota m. ACS Med Chem Lett. 2021 Apr 21;12(5):745-751. doi: 10.1021/acsmedchemlett.0c00679. eCollection 2021 May 13. ACS Med Chem Lett. 2021. PMID: 34055221 Free PMC article.
Synthesis and SAR of 2-phenyl-1-sulfonylaminocyclopropane carboxylates as ADAMTS-5 (Aggrecanase-2) inhibitors.
Shiozaki M, Imai H, Maeda K, Miura T, Yasue K, Suma A, Yokota M, Ogoshi Y, Haas J, Fryer AM, Laird ER, Littmann NM, Andrews SW, Josey JA, Mimura T, Shinozaki Y, Yoshiuchi H, Inaba T. Shiozaki M, et al. Among authors: yokota m. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6213-7. doi: 10.1016/j.bmcl.2009.08.093. Epub 2009 Sep 3. Bioorg Med Chem Lett. 2009. PMID: 19767207
Discovery of (1S,2R,3R)-2,3-dimethyl-2-phenyl-1-sulfamidocyclopropanecarboxylates: novel and highly selective aggrecanase inhibitors.
Shiozaki M, Maeda K, Miura T, Kotoku M, Yamasaki T, Matsuda I, Aoki K, Yasue K, Imai H, Ubukata M, Suma A, Yokota M, Hotta T, Tanaka M, Hase Y, Haas J, Fryer AM, Laird ER, Littmann NM, Andrews SW, Josey JA, Mimura T, Shinozaki Y, Yoshiuchi H, Inaba T. Shiozaki M, et al. Among authors: yokota m. J Med Chem. 2011 Apr 28;54(8):2839-63. doi: 10.1021/jm101609j. Epub 2011 Mar 21. J Med Chem. 2011. PMID: 21417219
Discovery of JTZ-951: A HIF Prolyl Hydroxylase Inhibitor for the Treatment of Renal Anemia.
Ogoshi Y, Matsui T, Mitani I, Yokota M, Terashita M, Motoda D, Ueyama K, Hotta T, Ito T, Hase Y, Fukui K, Deai K, Yoshiuchi H, Ito S, Abe H. Ogoshi Y, et al. Among authors: yokota m. ACS Med Chem Lett. 2017 Nov 20;8(12):1320-1325. doi: 10.1021/acsmedchemlett.7b00404. eCollection 2017 Dec 14. ACS Med Chem Lett. 2017. PMID: 29259755 Free PMC article.
Discovery of Second Generation RORγ Inhibitors Composed of an Azole Scaffold.
Kotoku M, Maeba T, Fujioka S, Yokota M, Seki N, Ito K, Suwa Y, Ikenogami T, Hirata K, Hase Y, Katsuda Y, Miyagawa N, Arita K, Asahina K, Noguchi M, Nomura A, Doi S, Adachi T, Crowe P, Tao H, Thacher S, Hashimoto H, Suzuki T, Shiozaki M. Kotoku M, et al. Among authors: yokota m. J Med Chem. 2019 Mar 14;62(5):2837-2842. doi: 10.1021/acs.jmedchem.8b01567. Epub 2019 Mar 1. J Med Chem. 2019. PMID: 30776227
Discovery and SAR of JTE-151: A Novel RORγ Inhibitor for Clinical Development.
Maeba T, Hirata K, Kotoku M, Seki N, Maeda K, Hirashima S, Yamanaka H, Sakai T, Obika S, Hori A, Hara Y, Noji S, Suwa Y, Yokota M, Fujioka S, Yamaguchi T, Katsuda Y, Hata T, Miyagawa N, Arita K, Nomura Y, Taniguchi T, Asahina K, Aratsu Y, Naka Y, Adachi T, Nomura A, Akai S, Oshida SI, Pai S, Crowe P, Bradley E, Steensma R, Tao H, Fenn M, Babine R, Li X, Thacher S, Soeta T, Ukaji Y, Shiozaki M. Maeba T, et al. Among authors: yokota m. J Med Chem. 2024 Jan 25;67(2):952-970. doi: 10.1021/acs.jmedchem.3c01933. Epub 2024 Jan 3. J Med Chem. 2024. PMID: 38170624
Monitoring ctDNA RAS Mutational Status in Metastatic Colorectal Cancer: A Trial Protocol of RAS-trace and RAS-trace-2 Studies.
Kataoka K, Yamada T, Shiozawa M, Takase N, Ito K, Yamazaki K, Watanabe J, Kudo T, Suto T, Matsumoto T, Murata K, Suwa Y, Boku S, Yasui H, Matsuhashi N, Maeda A, Sugimoto K, Matsumoto Y, Yokota M, Fredebohm J, Mori K, Ikeda M. Kataoka K, et al. Among authors: yokota m. J Anus Rectum Colon. 2024 Apr 25;8(2):132-136. doi: 10.23922/jarc.2023-051. eCollection 2024. J Anus Rectum Colon. 2024. PMID: 38689780 Free PMC article.
1,228 results