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Discovery of a Series of Indazole TRPA1 Antagonists.
Pryde DC, Marron BE, West CW, Reister S, Amato G, Yoger K, Antonio B, Padilla K, Cox PJ, Turner J, Warmus JS, Swain NA, Omoto K, Mahoney JH, Gerlach AC. Pryde DC, et al. Among authors: yoger k. ACS Med Chem Lett. 2017 May 18;8(6):666-671. doi: 10.1021/acsmedchemlett.7b00140. eCollection 2017 Jun 8. ACS Med Chem Lett. 2017. PMID: 28626530 Free PMC article.
TRPA1 ankyrin repeat six interacts with a small molecule inhibitor chemotype.
Tseng WC, Pryde DC, Yoger KE, Padilla KM, Antonio BM, Han S, Shanmugasundaram V, Gerlach AC. Tseng WC, et al. Among authors: yoger ke. Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):12301-12306. doi: 10.1073/pnas.1808142115. Epub 2018 Nov 14. Proc Natl Acad Sci U S A. 2018. PMID: 30429323 Free PMC article.
GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K2P ) channel opener, reduces rat dorsal root ganglion neuron excitability.
Loucif AJC, Saintot PP, Liu J, Antonio BM, Zellmer SG, Yoger K, Veale EL, Wilbrey A, Omoto K, Cao L, Gutteridge A, Castle NA, Stevens EB, Mathie A. Loucif AJC, et al. Among authors: yoger k. Br J Pharmacol. 2018 Jun;175(12):2272-2283. doi: 10.1111/bph.14098. Epub 2017 Dec 29. Br J Pharmacol. 2018. PMID: 29150838 Free PMC article.