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Exploring marine resources for bioactive compounds.
Kiuru P, DʼAuria MV, Muller CD, Tammela P, Vuorela H, Yli-Kauhaluoma J. Kiuru P, et al. Planta Med. 2014 Sep;80(14):1234-46. doi: 10.1055/s-0034-1383001. Epub 2014 Sep 9. Planta Med. 2014. PMID: 25203732 Review.
A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides.
Keurulainen L, Vahermo M, Puente-Felipe M, Sandoval-Izquierdo E, Crespo-Fernández B, Guijarro-López L, Huertas-Valentín L, de las Heras-Dueña L, Leino TO, Siiskonen A, Ballell-Pages L, Sanz LM, Castañeda-Casado P, Jiménez-Díaz MB, Martínez-Martínez MS, Viera S, Kiuru P, Calderón F, Yli-Kauhaluoma J. Keurulainen L, et al. J Med Chem. 2015 Jun 11;58(11):4573-80. doi: 10.1021/acs.jmedchem.5b00114. Epub 2015 May 19. J Med Chem. 2015. PMID: 25906200
Antibacterial profiling of abietane-type diterpenoids.
Helfenstein A, Vahermo M, Nawrot DA, Demirci F, İşcan G, Krogerus S, Yli-Kauhaluoma J, Moreira VM, Tammela P. Helfenstein A, et al. Bioorg Med Chem. 2017 Jan 1;25(1):132-137. doi: 10.1016/j.bmc.2016.10.019. Epub 2016 Oct 17. Bioorg Med Chem. 2017. PMID: 27793449
Adenosine analogs bearing phosphate isosteres as human MDO1 ligands.
Zhang Y, Jumppanen M, Maksimainen MM, Auno S, Awol Z, Ghemtio L, Venkannagari H, Lehtiö L, Yli-Kauhaluoma J, Xhaard H, Boije Af Gennäs G. Zhang Y, et al. Bioorg Med Chem. 2018 May 1;26(8):1588-1597. doi: 10.1016/j.bmc.2018.02.006. Epub 2018 Feb 13. Bioorg Med Chem. 2018. PMID: 29501416
159 results