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Partial DNA-guided Cas9 enables genome editing with reduced off-target activity.
Yin H, Song CQ, Suresh S, Kwan SY, Wu Q, Walsh S, Ding J, Bogorad RL, Zhu LJ, Wolfe SA, Koteliansky V, Xue W, Langer R, Anderson DG. Yin H, et al. Nat Chem Biol. 2018 Mar;14(3):311-316. doi: 10.1038/nchembio.2559. Epub 2018 Jan 29. Nat Chem Biol. 2018. PMID: 29377001 Free PMC article.
Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates.
Dong Y, Love KT, Dorkin JR, Sirirungruang S, Zhang Y, Chen D, Bogorad RL, Yin H, Chen Y, Vegas AJ, Alabi CA, Sahay G, Olejnik KT, Wang W, Schroeder A, Lytton-Jean AK, Siegwart DJ, Akinc A, Barnes C, Barros SA, Carioto M, Fitzgerald K, Hettinger J, Kumar V, Novobrantseva TI, Qin J, Querbes W, Koteliansky V, Langer R, Anderson DG. Dong Y, et al. Among authors: yin h. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):3955-60. doi: 10.1073/pnas.1322937111. Epub 2014 Feb 10. Proc Natl Acad Sci U S A. 2014. PMID: 24516150 Free PMC article.
Lipid-like nanomaterials for simultaneous gene expression and silencing in vivo.
Dong Y, Eltoukhy AA, Alabi CA, Khan OF, Veiseh O, Dorkin JR, Sirirungruang S, Yin H, Tang BC, Pelet JM, Chen D, Gu Z, Xue Y, Langer R, Anderson DG. Dong Y, et al. Among authors: yin h. Adv Healthc Mater. 2014 Sep;3(9):1392-7. doi: 10.1002/adhm.201400054. Epub 2014 Mar 13. Adv Healthc Mater. 2014. PMID: 24623658 Free PMC article.
In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight.
Dahlman JE, Barnes C, Khan O, Thiriot A, Jhunjunwala S, Shaw TE, Xing Y, Sager HB, Sahay G, Speciner L, Bader A, Bogorad RL, Yin H, Racie T, Dong Y, Jiang S, Seedorf D, Dave A, Sandu KS, Webber MJ, Novobrantseva T, Ruda VM, Lytton-Jean AKR, Levins CG, Kalish B, Mudge DK, Perez M, Abezgauz L, Dutta P, Smith L, Charisse K, Kieran MW, Fitzgerald K, Nahrendorf M, Danino D, Tuder RM, von Andrian UH, Akinc A, Schroeder A, Panigrahy D, Kotelianski V, Langer R, Anderson DG. Dahlman JE, et al. Among authors: yin h. Nat Nanotechnol. 2014 Aug;9(8):648-655. doi: 10.1038/nnano.2014.84. Epub 2014 May 11. Nat Nanotechnol. 2014. PMID: 24813696 Free PMC article.
Non-viral vectors for gene-based therapy.
Yin H, Kanasty RL, Eltoukhy AA, Vegas AJ, Dorkin JR, Anderson DG. Yin H, et al. Nat Rev Genet. 2014 Aug;15(8):541-55. doi: 10.1038/nrg3763. Epub 2014 Jul 15. Nat Rev Genet. 2014. PMID: 25022906 Review.
CRISPR-mediated direct mutation of cancer genes in the mouse liver.
Xue W, Chen S, Yin H, Tammela T, Papagiannakopoulos T, Joshi NS, Cai W, Yang G, Bronson R, Crowley DG, Zhang F, Anderson DG, Sharp PA, Jacks T. Xue W, et al. Among authors: yin h. Nature. 2014 Oct 16;514(7522):380-4. doi: 10.1038/nature13589. Epub 2014 Aug 6. Nature. 2014. PMID: 25119044 Free PMC article.
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