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141 results

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Page 1
Uptake, efficacy, and systemic distribution of naked, inhaled short interfering RNA (siRNA) and locked nucleic acid (LNA) antisense.
Moschos SA, Frick M, Taylor B, Turnpenny P, Graves H, Spink KG, Brady K, Lamb D, Collins D, Rockel TD, Weber M, Lazari O, Perez-Tosar L, Fancy SA, Lapthorn C, Green MX, Evans S, Selby M, Jones G, Jones L, Kearney S, Mechiche H, Gikunju D, Subramanian R, Uhlmann E, Jurk M, Vollmer J, Ciaramella G, Yeadon M. Moschos SA, et al. Among authors: yeadon m. Mol Ther. 2011 Dec;19(12):2163-8. doi: 10.1038/mt.2011.206. Epub 2011 Oct 4. Mol Ther. 2011. PMID: 21971426 Free PMC article.
Design and synthesis of long acting inhaled corticosteroids for the treatment of asthma.
Millan DS, Ballard SA, Chunn S, Dybowski JA, Fulton CK, Glossop PA, Guillabert E, Hewson CA, Jones RM, Lamb DJ, Napier CM, Payne-Cook TA, Renery ER, Selby MD, Tutt MF, Yeadon M. Millan DS, et al. Among authors: yeadon m. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5826-30. doi: 10.1016/j.bmcl.2011.07.106. Epub 2011 Aug 11. Bioorg Med Chem Lett. 2011. PMID: 21880489
Inhaled adenosine A(2A) receptor agonists for the treatment of chronic obstructive pulmonary disease.
Mantell SJ, Stephenson PT, Monaghan SM, Maw GN, Trevethick MA, Yeadon M, Keir RF, Walker DK, Jones RM, Selby MD, Batchelor DV, Rozze S, Chavaroche H, Hobson TJ, Dodd PG, Lemaitre A, Wright KN, Stuart EF. Mantell SJ, et al. Among authors: yeadon m. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1284-7. doi: 10.1016/j.bmcl.2008.01.033. Epub 2008 Jan 12. Bioorg Med Chem Lett. 2008. PMID: 18243699
SAR of a series of inhaled A(2A) agonists and comparison of inhaled pharmacokinetics in a preclinical model with clinical pharmacokinetic data.
Mantell SJ, Stephenson PT, Monaghan SM, Maw GN, Trevethick MA, Yeadon M, Walker DK, Selby MD, Batchelor DV, Rozze S, Chavaroche H, Lemaitre A, Wright KN, Whitlock L, Stuart EF, Wright PA, Macintyre F. Mantell SJ, et al. Among authors: yeadon m. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4471-5. doi: 10.1016/j.bmcl.2009.05.027. Epub 2009 May 12. Bioorg Med Chem Lett. 2009. PMID: 19501510
Design and synthesis of inhaled p38 inhibitors for the treatment of chronic obstructive pulmonary disease.
Millan DS, Bunnage ME, Burrows JL, Butcher KJ, Dodd PG, Evans TJ, Fairman DA, Hughes SJ, Kilty IC, Lemaitre A, Lewthwaite RA, Mahnke A, Mathias JP, Philip J, Smith RT, Stefaniak MH, Yeadon M, Phillips C. Millan DS, et al. Among authors: yeadon m. J Med Chem. 2011 Nov 24;54(22):7797-814. doi: 10.1021/jm200677b. Epub 2011 Oct 28. J Med Chem. 2011. PMID: 21888439
Inhalation by design: novel ultra-long-acting β(2)-adrenoreceptor agonists for inhaled once-daily treatment of asthma and chronic obstructive pulmonary disease that utilize a sulfonamide agonist headgroup.
Glossop PA, Lane CA, Price DA, Bunnage ME, Lewthwaite RA, James K, Brown AD, Yeadon M, Perros-Huguet C, Trevethick MA, Clarke NP, Webster R, Jones RM, Burrows JL, Feeder N, Taylor SC, Spence FJ. Glossop PA, et al. Among authors: yeadon m. J Med Chem. 2010 Sep 23;53(18):6640-52. doi: 10.1021/jm1005989. J Med Chem. 2010. PMID: 20804199
Inhalation by design: novel tertiary amine muscarinic M₃ receptor antagonists with slow off-rate binding kinetics for inhaled once-daily treatment of chronic obstructive pulmonary disease.
Glossop PA, Watson CA, Price DA, Bunnage ME, Middleton DS, Wood A, James K, Roberts D, Strang RS, Yeadon M, Perros-Huguet C, Clarke NP, Trevethick MA, Machin I, Stuart EF, Evans SM, Harrison AC, Fairman DA, Agoram B, Burrows JL, Feeder N, Fulton CK, Dillon BR, Entwistle DA, Spence FJ. Glossop PA, et al. Among authors: yeadon m. J Med Chem. 2011 Oct 13;54(19):6888-904. doi: 10.1021/jm200884j. Epub 2011 Sep 20. J Med Chem. 2011. PMID: 21870878 Clinical Trial.
141 results