Brain iron loading impairs DNA methylation and alters GABAergic function in mice.
Ye Q, Trivedi M, Zhang Y, Böhlke M, Alsulimani H, Chang J, Maher T, Deth R, Kim J.
Ye Q, et al.
FASEB J. 2019 Feb;33(2):2460-2471. doi: 10.1096/fj.201801116RR. Epub 2018 Oct 2.
FASEB J. 2019.
PMID: 30277817
Free PMC article.
Taken together, our results suggest a putative role of HFE in regulating labile iron status in the brain, and mutation in H67D perturbs redox-methylation status, contributing to GABAergic dysfunction.-Ye, Q., Trivedi, M., Zhang, Y., Bohlke, M., Alsulimani, H., Chang …
Taken together, our results suggest a putative role of HFE in regulating labile iron status in the brain, and mutation in H67D perturbs redo …