Pharmacokinetics of Nuciferine and N-Nornuciferine, Two Major Alkaloids From Nelumbo nucifera Leaves, in Rat Plasma and the Brain.
Ye LH, He XX, You C, Tao X, Wang LS, Zhang MD, Zhou YF, Chang Q.
Ye LH, et al.
Front Pharmacol. 2018 Aug 29;9:902. doi: 10.3389/fphar.2018.00902. eCollection 2018.
Front Pharmacol. 2018.
PMID: 30210336
Free PMC article.
After i.v. administration (10 mg/kg), NF and N-NF were found to have a relatively wide volume of distribution (V(d, lambdaz), 9.48 and 15.17 L/kg, respectively) and slow elimination half-life (t(1/2, lambdaz), 2.09 and 3.84 h, respectively). ...Both alkaloids had widesprea …
After i.v. administration (10 mg/kg), NF and N-NF were found to have a relatively wide volume of distribution (V(d, lambdaz), 9.48 and 15.17 …