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A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression.
Verginadis II, Avgousti H, Monslow J, Skoufos G, Chinga F, Kim K, Leli NM, Karagounis IV, Bell BI, Velalopoulou A, Salinas CS, Wu VS, Li Y, Ye J, Scott DA, Osterman AL, Sengupta A, Weljie A, Huang M, Zhang D, Fan Y, Radaelli E, Tobias JW, Rambow F, Karras P, Marine JC, Xu X, Hatzigeorgiou AG, Ryeom S, Diehl JA, Fuchs SY, Puré E, Koumenis C. Verginadis II, et al. Among authors: ye j. Nat Cell Biol. 2022 Jun;24(6):940-953. doi: 10.1038/s41556-022-00918-8. Epub 2022 Jun 2. Nat Cell Biol. 2022. PMID: 35654839 Free PMC article.
The magic bullet: Niclosamide.
Jiang H, Li AM, Ye J. Jiang H, et al. Among authors: ye j. Front Oncol. 2022 Nov 21;12:1004978. doi: 10.3389/fonc.2022.1004978. eCollection 2022. Front Oncol. 2022. PMID: 36479072 Free PMC article. Review.
PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy.
Zhang D, Li AM, Hu G, Huang M, Yang F, Zhang L, Wellen KE, Xu X, Conn CS, Zou W, Kahn M, Rhoades SD, Weljie AM, Fuchs SY, Amankulor N, Yoshor D, Ye J, Koumenis C, Gong Y, Fan Y. Zhang D, et al. Among authors: ye j. Cell Metab. 2023 Mar 7;35(3):517-534.e8. doi: 10.1016/j.cmet.2023.01.010. Epub 2023 Feb 17. Cell Metab. 2023. PMID: 36804058 Free PMC article.
Serine starvation silences estrogen receptor signaling through histone hypoacetylation.
Li AM, He B, Karagiannis D, Li Y, Jiang H, Srinivasan P, Ramirez Y, Zhou MN, Curtis C, Gruber JJ, Lu C, Rankin EB, Ye J. Li AM, et al. Among authors: ye j. Proc Natl Acad Sci U S A. 2023 Sep 19;120(38):e2302489120. doi: 10.1073/pnas.2302489120. Epub 2023 Sep 11. Proc Natl Acad Sci U S A. 2023. PMID: 37695911 Free PMC article.
Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell phenotype.
Viswanathan V, Cao H, Saiki J, Jiang D, Mattingly A, Nambiar D, Bloomstein J, Li Y, Jiang S, Chamoli M, Sirjani D, Kaplan M, Holsinger FC, Liang R, Von Eyben R, Jiang H, Guan L, Lagory E, Feng Z, Nolan G, Ye J, Denko N, Knox S, Rosen DM, Le QT. Viswanathan V, et al. Among authors: ye j. PNAS Nexus. 2022 Jun 9;1(2):pgac056. doi: 10.1093/pnasnexus/pgac056. eCollection 2022 May. PNAS Nexus. 2022. PMID: 35707206 Free PMC article.
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