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Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2.
Bernstock JD, Ye D, Smith JA, Lee YJ, Gessler FA, Yasgar A, Kouznetsova J, Jadhav A, Wang Z, Pluchino S, Zheng W, Simeonov A, Hallenbeck JM, Yang W. Bernstock JD, et al. Among authors: ye d. FASEB J. 2018 Mar;32(3):1677-1691. doi: 10.1096/fj.201700711R. Epub 2018 Jan 3. FASEB J. 2018. PMID: 29146736 Free PMC article.
Herein, we describe a process capable of identifying and characterizing small molecules with the potential of targeting the SUMO system through inhibition of SUMO deconjugation in an effort to develop novel stroke therapies.-Bernstock, J. D., Ye, D., Smith, J …
Herein, we describe a process capable of identifying and characterizing small molecules with the potential of targeting the SUMO system thro …
SUMOylation in brain ischemia: Patterns, targets, and translational implications.
Bernstock JD, Yang W, Ye DG, Shen Y, Pluchino S, Lee YJ, Hallenbeck JM, Paschen W. Bernstock JD, et al. Among authors: ye dg. J Cereb Blood Flow Metab. 2018 Jan;38(1):5-16. doi: 10.1177/0271678X17742260. Epub 2017 Nov 17. J Cereb Blood Flow Metab. 2018. PMID: 29148315 Free PMC article. Review.
Drugging SUMOylation for neuroprotection and oncotherapy.
Bernstock JD, Ye DG, Lee YJ, Gessler F, Friedman GK, Zheng W, Hallenbeck JM. Bernstock JD, et al. Among authors: ye dg. Neural Regen Res. 2018 Mar;13(3):415-416. doi: 10.4103/1673-5374.228718. Neural Regen Res. 2018. PMID: 29623920 Free PMC article. No abstract available.
SUMOylation promotes survival and integration of neural stem cell grafts in ischemic stroke.
Bernstock JD, Peruzzotti-Jametti L, Leonardi T, Vicario N, Ye D, Lee YJ, Maric D, Johnson KR, Mou Y, Van Den Bosch A, Winterbone M, Friedman GK, Franklin RJM, Hallenbeck JM, Pluchino S. Bernstock JD, et al. Among authors: ye d. EBioMedicine. 2019 Apr;42:214-224. doi: 10.1016/j.ebiom.2019.03.035. Epub 2019 Mar 21. EBioMedicine. 2019. PMID: 30905846 Free PMC article.
3,674 results