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Page 1
Mammalian γ2 AMPK regulates intrinsic heart rate.
Yavari A, Bellahcene M, Bucchi A, Sirenko S, Pinter K, Herring N, Jung JJ, Tarasov KV, Sharpe EJ, Wolfien M, Czibik G, Steeples V, Ghaffari S, Nguyen C, Stockenhuber A, Clair JRS, Rimmbach C, Okamoto Y, Yang D, Wang M, Ziman BD, Moen JM, Riordon DR, Ramirez C, Paina M, Lee J, Zhang J, Ahmet I, Matt MG, Tarasova YS, Baban D, Sahgal N, Lockstone H, Puliyadi R, de Bono J, Siggs OM, Gomes J, Muskett H, Maguire ML, Beglov Y, Kelly M, Dos Santos PPN, Bright NJ, Woods A, Gehmlich K, Isackson H, Douglas G, Ferguson DJP, Schneider JE, Tinker A, Wolkenhauer O, Channon KM, Cornall RJ, Sternick EB, Paterson DJ, Redwood CS, Carling D, Proenza C, David R, Baruscotti M, DiFrancesco D, Lakatta EG, Watkins H, Ashrafian H. Yavari A, et al. Nat Commun. 2017 Nov 2;8(1):1258. doi: 10.1038/s41467-017-01342-5. Nat Commun. 2017. PMID: 29097735 Free PMC article.
Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.
Ashrafian H, Czibik G, Bellahcene M, Aksentijević D, Smith AC, Mitchell SJ, Dodd MS, Kirwan J, Byrne JJ, Ludwig C, Isackson H, Yavari A, Støttrup NB, Contractor H, Cahill TJ, Sahgal N, Ball DR, Birkler RI, Hargreaves I, Tennant DA, Land J, Lygate CA, Johannsen M, Kharbanda RK, Neubauer S, Redwood C, de Cabo R, Ahmet I, Talan M, Günther UL, Robinson AJ, Viant MR, Pollard PJ, Tyler DJ, Watkins H. Ashrafian H, et al. Among authors: yavari a. Cell Metab. 2012 Mar 7;15(3):361-71. doi: 10.1016/j.cmet.2012.01.017. Cell Metab. 2012. PMID: 22405071 Free PMC article.
Citric acid cycle intermediates in cardioprotection.
Czibik G, Steeples V, Yavari A, Ashrafian H. Czibik G, et al. Among authors: yavari a. Circ Cardiovasc Genet. 2014 Oct;7(5):711-9. doi: 10.1161/CIRCGENETICS.114.000220. Circ Cardiovasc Genet. 2014. PMID: 25518044 Review.
iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death.
Notari M, Hu Y, Sutendra G, Dedeić Z, Lu M, Dupays L, Yavari A, Carr CA, Zhong S, Opel A, Tinker A, Clarke K, Watkins H, Ferguson DJ, Kelsell DP, de Noronha S, Sheppard MN, Hollinshead M, Mohun TJ, Lu X. Notari M, et al. Among authors: yavari a. Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):E973-81. doi: 10.1073/pnas.1408111112. Epub 2015 Feb 17. Proc Natl Acad Sci U S A. 2015. PMID: 25691752 Free PMC article.
Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If: Novel electrophysiological insights and therapeutic potential.
Capel RA, Herring N, Kalla M, Yavari A, Mirams GR, Douglas G, Bub G, Channon K, Paterson DJ, Terrar DA, Burton RA. Capel RA, et al. Among authors: yavari a. Heart Rhythm. 2015 Oct;12(10):2186-94. doi: 10.1016/j.hrthm.2015.05.027. Epub 2015 May 27. Heart Rhythm. 2015. PMID: 26025323 Free PMC article.
Effect of Selective Heart Rate Slowing in Heart Failure With Preserved Ejection Fraction.
Pal N, Sivaswamy N, Mahmod M, Yavari A, Rudd A, Singh S, Dawson DK, Francis JM, Dwight JS, Watkins H, Neubauer S, Frenneaux M, Ashrafian H. Pal N, et al. Among authors: yavari a. Circulation. 2015 Nov 3;132(18):1719-25. doi: 10.1161/CIRCULATIONAHA.115.017119. Epub 2015 Sep 2. Circulation. 2015. PMID: 26338956 Free PMC article. Clinical Trial.
Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure.
Cahill TJ, Leo V, Kelly M, Stockenhuber A, Kennedy NW, Bao L, Cereghetti GM, Harper AR, Czibik G, Liao C, Bellahcene M, Steeples V, Ghaffari S, Yavari A, Mayer A, Poulton J, Ferguson DJ, Scorrano L, Hettiarachchi NT, Peers C, Boyle J, Hill RB, Simmons A, Watkins H, Dear TN, Ashrafian H. Cahill TJ, et al. Among authors: yavari a. J Biol Chem. 2015 Oct 23;290(43):25907-19. doi: 10.1074/jbc.M115.665695. Epub 2015 Sep 14. J Biol Chem. 2015. PMID: 26370078 Free PMC article.
120 results