Yang Y - Search Results

1

The m⁶A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia.

Weng H, Huang F, Yu Z, Chen Z, Prince E, Kang Y, Zhou K, Li W, Hu J, Fu C, Aziz T, Li H, Li J, Yang Y, Han L, Zhang S, Ma Y, Sun M, Wu H, Zhang Z, Wunderlich M, Robinson S, Braas D, Hoeve JT, Zhang B, Marcucci G, Mulloy JC, Zhou K, Tao HF, Deng X, Horne D, Wei M, Huang H, Chen J. Weng H, et al. Among authors: yang y. Cancer Cell. 2022 Dec 12;40(12):1566-1582.e10. doi: 10.1016/j.ccell.2022.10.004. Epub 2022 Oct 27. Cancer Cell. 2022. PMID: 36306790 Free PMC article.

2

p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by Upregulating Slc7a3 to Increase Arginine Uptake.

Lowman XH, Hanse EA, Yang Y, Ishak Gabra MB, Tran TQ, Li H, Kong M. Lowman XH, et al. Among authors: yang y. Cell Rep. 2019 Mar 12;26(11):3051-3060.e4. doi: 10.1016/j.celrep.2019.02.037. Cell Rep. 2019. PMID: 30865893 Free PMC article.

3

Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation.

Pan M, Reid MA, Lowman XH, Kulkarni RP, Tran TQ, Liu X, Yang Y, Hernandez-Davies JE, Rosales KK, Li H, Hugo W, Song C, Xu X, Schones DE, Ann DK, Gradinaru V, Lo RS, Locasale JW, Kong M. Pan M, et al. Among authors: yang y. Nat Cell Biol. 2016 Oct;18(10):1090-101. doi: 10.1038/ncb3410. Epub 2016 Sep 12. Nat Cell Biol. 2016. PMID: 27617932 Free PMC article.

4

α-Ketoglutarate attenuates Wnt signaling and drives differentiation in colorectal cancer.

Tran TQ, Hanse EA, Habowski AN, Li H, Ishak Gabra MB, Yang Y, Lowman XH, Ooi AM, Liao SY, Edwards RA, Waterman ML, Kong M. Tran TQ, et al. Among authors: yang y. Nat Cancer. 2020 Mar;1(3):345-358. doi: 10.1038/s43018-020-0035-5. Epub 2020 Mar 20. Nat Cancer. 2020. PMID: 32832918 Free PMC article.

5

Glutamine deficiency induces DNA alkylation damage and sensitizes cancer cells to alkylating agents through inhibition of ALKBH enzymes.

Tran TQ, Ishak Gabra MB, Lowman XH, Yang Y, Reid MA, Pan M, O'Connor TR, Kong M. Tran TQ, et al. Among authors: yang y. PLoS Biol. 2017 Nov 6;15(11):e2002810. doi: 10.1371/journal.pbio.2002810. eCollection 2017 Nov. PLoS Biol. 2017. PMID: 29107960 Free PMC article.

6

Vemurafenib resistance reprograms melanoma cells towards glutamine dependence.

Hernandez-Davies JE, Tran TQ, Reid MA, Rosales KR, Lowman XH, Pan M, Moriceau G, Yang Y, Wu J, Lo RS, Kong M. Hernandez-Davies JE, et al. Among authors: yang y. J Transl Med. 2015 Jul 3;13:210. doi: 10.1186/s12967-015-0581-2. J Transl Med. 2015. PMID: 26139106 Free PMC article.

7

NADP⁺ is an endogenous PARP inhibitor in DNA damage response and tumor suppression.

Bian C, Zhang C, Luo T, Vyas A, Chen SH, Liu C, Kassab MA, Yang Y, Kong M, Yu X. Bian C, et al. Among authors: yang y. Nat Commun. 2019 Feb 11;10(1):693. doi: 10.1038/s41467-019-08530-5. Nat Commun. 2019. PMID: 30741937 Free PMC article.

8

CARM1 suppresses de novo serine synthesis by promoting PKM2 activity.

Abeywardana T, Oh M, Jiang L, Yang Y, Kong M, Song J, Yang Y. Abeywardana T, et al. Among authors: yang y. J Biol Chem. 2018 Sep 28;293(39):15290-15303. doi: 10.1074/jbc.RA118.004512. Epub 2018 Aug 21. J Biol Chem. 2018. PMID: 30131339 Free PMC article.

9

SAPS3 subunit of protein phosphatase 6 is an AMPK inhibitor and controls metabolic homeostasis upon dietary challenge in male mice.

Yang Y, Reid MA, Hanse EA, Li H, Li Y, Ruiz BI, Fan Q, Kong M. Yang Y, et al. Nat Commun. 2023 Mar 13;14(1):1368. doi: 10.1038/s41467-023-36809-1. Nat Commun. 2023. PMID: 36914647 Free PMC article.

10

IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3.

Reid MA, Lowman XH, Pan M, Tran TQ, Warmoes MO, Ishak Gabra MB, Yang Y, Locasale JW, Kong M. Reid MA, et al. Among authors: yang y. Genes Dev. 2016 Aug 15;30(16):1837-51. doi: 10.1101/gad.287235.116. Epub 2016 Sep 1. Genes Dev. 2016. PMID: 27585591 Free PMC article.

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