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Membrane transporters in drug development and as determinants of precision medicine.
Galetin A, Brouwer KLR, Tweedie D, Yoshida K, Sjöstedt N, Aleksunes L, Chu X, Evers R, Hafey MJ, Lai Y, Matsson P, Riselli A, Shen H, Sparreboom A, Varma MVS, Yang J, Yang X, Yee SW, Zamek-Gliszczynski MJ, Zhang L, Giacomini KM. Galetin A, et al. Among authors: yang x, yang j. Nat Rev Drug Discov. 2024 Apr;23(4):255-280. doi: 10.1038/s41573-023-00877-1. Epub 2024 Jan 24. Nat Rev Drug Discov. 2024. PMID: 38267543 Review.
Intestinal P-gp and Putative Hepatic OATP1B Induction: International Transporter Consortium Perspective on Drug Development Implications.
Zamek-Gliszczynski MJ, Patel M, Yang X, Lutz JD, Chu X, Brouwer KLR, Lai Y, Lee CA, Neuhoff S, Paine MF, Sugiyama Y, Taskar KS, Galetin A. Zamek-Gliszczynski MJ, et al. Among authors: yang x. Clin Pharmacol Ther. 2021 Jan;109(1):55-64. doi: 10.1002/cpt.1916. Epub 2020 Jul 9. Clin Pharmacol Ther. 2021. PMID: 32460379 Free PMC article. Review.
How Science Is Driving Regulatory Guidances.
Yang X, Fan J, Zhang L. Yang X, et al. Methods Mol Biol. 2021;2342:595-629. doi: 10.1007/978-1-0716-1554-6_19. Methods Mol Biol. 2021. PMID: 34272707
Clinical Relevance of Hepatic and Renal P-gp/BCRP Inhibition of Drugs: An International Transporter Consortium Perspective.
Taskar KS, Yang X, Neuhoff S, Patel M, Yoshida K, Paine MF, Brouwer KLR, Chu X, Sugiyama Y, Cook J, Polli JW, Hanna I, Lai Y, Zamek-Gliszczynski M; ITC. Taskar KS, et al. Among authors: yang x. Clin Pharmacol Ther. 2022 Sep;112(3):573-592. doi: 10.1002/cpt.2670. Epub 2022 Jun 22. Clin Pharmacol Ther. 2022. PMID: 35612761 Free PMC article. Review.
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