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IL-27 signalling promotes adipocyte thermogenesis and energy expenditure.
Wang Q, Li D, Cao G, Shi Q, Zhu J, Zhang M, Cheng H, Wen Q, Xu H, Zhu L, Zhang H, Perry RJ, Spadaro O, Yang Y, He S, Chen Y, Wang B, Li G, Liu Z, Yang C, Wu X, Zhou L, Zhou Q, Ju Z, Lu H, Xin Y, Yang X, Wang C, Liu Y, Shulman GI, Dixit VD, Lu L, Yang H, Flavell RA, Yin Z. Wang Q, et al. Among authors: yang c, yang x, yang h, yang y. Nature. 2021 Dec;600(7888):314-318. doi: 10.1038/s41586-021-04127-5. Epub 2021 Nov 24. Nature. 2021. PMID: 34819664
Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression.
Lee Y, Dominy JE, Choi YJ, Jurczak M, Tolliday N, Camporez JP, Chim H, Lim JH, Ruan HB, Yang X, Vazquez F, Sicinski P, Shulman GI, Puigserver P. Lee Y, et al. Among authors: yang x. Nature. 2014 Jun 26;510(7506):547-51. doi: 10.1038/nature13267. Epub 2014 May 25. Nature. 2014. PMID: 24870244 Free PMC article.
Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes.
Perry RJ, Camporez JG, Kursawe R, Titchenell PM, Zhang D, Perry CJ, Jurczak MJ, Abudukadier A, Han MS, Zhang XM, Ruan HB, Yang X, Caprio S, Kaech SM, Sul HS, Birnbaum MJ, Davis RJ, Cline GW, Petersen KF, Shulman GI. Perry RJ, et al. Among authors: yang x. Cell. 2015 Feb 12;160(4):745-758. doi: 10.1016/j.cell.2015.01.012. Epub 2015 Feb 5. Cell. 2015. PMID: 25662011 Free PMC article.
Hepatic Inositol 1,4,5 Trisphosphate Receptor Type 1 Mediates Fatty Liver.
Feriod CN, Oliveira AG, Guerra MT, Nguyen L, Richards KM, Jurczak MJ, Ruan HB, Camporez JP, Yang X, Shulman GI, Bennett AM, Nathanson MH, Ehrlich BE. Feriod CN, et al. Among authors: yang x. Hepatol Commun. 2017 Feb;1(1):23-35. doi: 10.1002/hep4.1012. Epub 2016 Nov 11. Hepatol Commun. 2017. PMID: 28966992 Free PMC article.
Adipocyte OGT governs diet-induced hyperphagia and obesity.
Li MD, Vera NB, Yang Y, Zhang B, Ni W, Ziso-Qejvanaj E, Ding S, Zhang K, Yin R, Wang S, Zhou X, Fang EX, Xu T, Erion DM, Yang X. Li MD, et al. Among authors: yang x, yang y. Nat Commun. 2018 Nov 30;9(1):5103. doi: 10.1038/s41467-018-07461-x. Nat Commun. 2018. PMID: 30504766 Free PMC article.
OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance.
Yang Y, Li X, Luan HH, Zhang B, Zhang K, Nam JH, Li Z, Fu M, Munk A, Zhang D, Wang S, Liu Y, Albuquerque JP, Ong Q, Li R, Wang Q, Robert ME, Perry RJ, Chung D, Shulman GI, Yang X. Yang Y, et al. Among authors: yang x. Proc Natl Acad Sci U S A. 2020 Jul 14;117(28):16616-16625. doi: 10.1073/pnas.1916121117. Epub 2020 Jun 29. Proc Natl Acad Sci U S A. 2020. PMID: 32601203 Free PMC article.
The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.
Dominy JE Jr, Lee Y, Jedrychowski MP, Chim H, Jurczak MJ, Camporez JP, Ruan HB, Feldman J, Pierce K, Mostoslavsky R, Denu JM, Clish CB, Yang X, Shulman GI, Gygi SP, Puigserver P. Dominy JE Jr, et al. Among authors: yang x. Mol Cell. 2012 Dec 28;48(6):900-13. doi: 10.1016/j.molcel.2012.09.030. Epub 2012 Nov 8. Mol Cell. 2012. PMID: 23142079 Free PMC article.
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