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The existence of a nonclassical TCA cycle in the nucleus that wires the metabolic-epigenetic circuitry.
Liu X, Si W, He L, Yang J, Peng Y, Ren J, Liu X, Jin T, Yu H, Zhang Z, Cheng X, Zhang W, Xia L, Huang Y, Wang Y, Liu S, Shan L, Zhang Y, Yang X, Li H, Liang J, Sun L, Shang Y. Liu X, et al. Among authors: yang x, yang j. Signal Transduct Target Ther. 2021 Nov 3;6(1):375. doi: 10.1038/s41392-021-00774-2. Signal Transduct Target Ther. 2021. PMID: 34728602 Free PMC article.
LSD1 is required for euchromatic origin firing and replication timing.
Wang Y, Huang Y, Cheng E, Liu X, Zhang Y, Yang J, Young JTF, Brown GW, Yang X, Shang Y. Wang Y, et al. Among authors: yang x, yang j. Signal Transduct Target Ther. 2022 Apr 13;7(1):102. doi: 10.1038/s41392-022-00927-x. Signal Transduct Target Ther. 2022. PMID: 35414135 Free PMC article.
UHRF2 commissions the completion of DNA demethylation through allosteric activation by 5hmC and K33-linked ubiquitination of XRCC1.
Liu X, Xu B, Yang J, He L, Zhang Z, Cheng X, Yu H, Liu X, Jin T, Peng Y, Huang Y, Xia L, Wang Y, Wu J, Wu X, Liu S, Shan L, Yang X, Sun L, Liang J, Zhang Y, Shang Y. Liu X, et al. Among authors: yang x, yang j. Mol Cell. 2021 Jul 15;81(14):2960-2974.e7. doi: 10.1016/j.molcel.2021.05.022. Epub 2021 Jun 9. Mol Cell. 2021. PMID: 34111398 Free article.
ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin.
Li L, Liu X, He L, Yang J, Pei F, Li W, Liu S, Chen Z, Xie G, Xu B, Ting X, Zhang Z, Jin T, Liu X, Zhang W, Yuan S, Yang Z, Wu C, Zhang Y, Yang X, Yi X, Liang J, Shang Y, Sun L. Li L, et al. Among authors: yang x, yang j, yang z. Nat Commun. 2017 Sep 25;8(1):691. doi: 10.1038/s41467-017-00702-5. Nat Commun. 2017. PMID: 28947780 Free PMC article.
Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis.
He L, Liu X, Yang J, Li W, Liu S, Liu X, Yang Z, Ren J, Wang Y, Shan L, Guan C, Pei F, Lei L, Zhang Y, Yi X, Yang X, Liang J, Liu R, Sun L, Shang Y. He L, et al. Among authors: yang x, yang j, yang z. Cell Res. 2018 Sep;28(9):934-951. doi: 10.1038/s41422-018-0079-6. Epub 2018 Aug 22. Cell Res. 2018. PMID: 30135474 Free PMC article.
TRPS1 drives heterochromatic origin refiring and cancer genome evolution.
Yang J, Liu X, Huang Y, He L, Zhang W, Ren J, Wang Y, Wu J, Wu X, Shan L, Yang X, Sun L, Liang J, Zhang Y, Shang Y. Yang J, et al. Among authors: yang x. Cell Rep. 2021 Mar 9;34(10):108814. doi: 10.1016/j.celrep.2021.108814. Cell Rep. 2021. PMID: 33691114 Free article.
SCFJFK is functionally linked to obesity and metabolic syndrome.
He L, Yan R, Yang Z, Zhang Y, Liu X, Yang J, Liu X, Liu X, Xia L, Wang Y, Wu J, Wu X, Shan L, Yang X, Liang J, Shang Y, Sun L. He L, et al. Among authors: yang x, yang z, yang j. EMBO Rep. 2021 Jul 5;22(7):e52036. doi: 10.15252/embr.202052036. Epub 2021 Jun 11. EMBO Rep. 2021. PMID: 34114325 Free PMC article.
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