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Investigating the purpose of prelamin A processing.
Davies BS, Coffinier C, Yang SH, Barnes RH 2nd, Jung HJ, Young SG, Fong LG. Davies BS, et al. Among authors: yang sh. Nucleus. 2011 Jan-Feb;2(1):4-9. doi: 10.4161/nucl.2.1.13723. Nucleus. 2011. PMID: 21647293 Free PMC article. Review.
Prelamin A and lamin A appear to be dispensable in the nuclear lamina.
Fong LG, Ng JK, Lammerding J, Vickers TA, Meta M, Coté N, Gavino B, Qiao X, Chang SY, Young SR, Yang SH, Stewart CL, Lee RT, Bennett CF, Bergo MO, Young SG. Fong LG, et al. Among authors: yang sh. J Clin Invest. 2006 Mar;116(3):743-52. doi: 10.1172/JCI27125. J Clin Invest. 2006. PMID: 16511604 Free PMC article.
Prelamin A farnesylation and progeroid syndromes.
Young SG, Meta M, Yang SH, Fong LG. Young SG, et al. Among authors: yang sh. J Biol Chem. 2006 Dec 29;281(52):39741-5. doi: 10.1074/jbc.R600033200. Epub 2006 Nov 7. J Biol Chem. 2006. PMID: 17090536 Free article. Review.
Activating the synthesis of progerin, the mutant prelamin A in Hutchinson-Gilford progeria syndrome, with antisense oligonucleotides.
Fong LG, Vickers TA, Farber EA, Choi C, Yun UJ, Hu Y, Yang SH, Coffinier C, Lee R, Yin L, Davies BS, Andres DA, Spielmann HP, Bennett CF, Young SG. Fong LG, et al. Among authors: yang sh. Hum Mol Genet. 2009 Jul 1;18(13):2462-71. doi: 10.1093/hmg/ddp184. Epub 2009 Apr 17. Hum Mol Genet. 2009. PMID: 19376814 Free PMC article.
The posttranslational processing of prelamin A and disease.
Davies BS, Fong LG, Yang SH, Coffinier C, Young SG. Davies BS, et al. Among authors: yang sh. Annu Rev Genomics Hum Genet. 2009;10:153-74. doi: 10.1146/annurev-genom-082908-150150. Annu Rev Genomics Hum Genet. 2009. PMID: 19453251 Free PMC article. Review.
Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice.
Coffinier C, Jung HJ, Li Z, Nobumori C, Yun UJ, Farber EA, Davies BS, Weinstein MM, Yang SH, Lammerding J, Farahani JN, Bentolila LA, Fong LG, Young SG. Coffinier C, et al. Among authors: yang sh. J Biol Chem. 2010 Jul 2;285(27):20818-26. doi: 10.1074/jbc.M110.128835. Epub 2010 May 3. J Biol Chem. 2010. PMID: 20439468 Free PMC article.
2,767 results