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Key steps in the structure-based optimization of the hepatitis C virus NS3/4A protease inhibitor SCH503034.
Madison V, Prongay AJ, Guo Z, Yao N, Pichardo J, Fischmann T, Strickland C, Myers J Jr, Weber PC, Beyer BM, Ingram R, Hong Z, Prosise WW, Ramanathan L, Taremi SS, Yarosh-Tomaine T, Zhang R, Senior M, Yang RS, Malcolm B, Arasappan A, Bennett F, Bogen SL, Chen K, Jao E, Liu YT, Lovey RG, Saksena AK, Venkatraman S, Girijavallabhan V, Njoroge FG. Madison V, et al. Among authors: yang rs. J Synchrotron Radiat. 2008 May;15(Pt 3):204-7. doi: 10.1107/S0909049507064229. Epub 2008 Apr 18. J Synchrotron Radiat. 2008. PMID: 18421139 Free PMC article.
Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization.
Prongay AJ, Guo Z, Yao N, Pichardo J, Fischmann T, Strickland C, Myers J Jr, Weber PC, Beyer BM, Ingram R, Hong Z, Prosise WW, Ramanathan L, Taremi SS, Yarosh-Tomaine T, Zhang R, Senior M, Yang RS, Malcolm B, Arasappan A, Bennett F, Bogen SL, Chen K, Jao E, Liu YT, Lovey RG, Saksena AK, Venkatraman S, Girijavallabhan V, Njoroge FG, Madison V. Prongay AJ, et al. Among authors: yang rs. J Med Chem. 2007 May 17;50(10):2310-8. doi: 10.1021/jm060173k. Epub 2007 Apr 20. J Med Chem. 2007. PMID: 17444623
Retraction: Advanced Glycation End Products Induce Peroxisome Proliferator-Activated Receptor γ Down-Regulation-Related Inflammatory Signals in Human Chondrocytes via Toll-Like Receptor-4 and Receptor for Advanced Glycation End Products.
Chen YJ, Sheu ML, Tsai KS, Yang RS, Liu SH. Chen YJ, et al. Among authors: yang rs. PLoS One. 2024 May 1;19(5):e0303122. doi: 10.1371/journal.pone.0303122. eCollection 2024. PLoS One. 2024. PMID: 38691543 Free PMC article. No abstract available.
Asia-Pacific consensus on long-term and sequential therapy for osteoporosis.
Tai TW, Chen HY, Shih CA, Huang CF, McCloskey E, Lee JK, Yeap SS, Cheung CL, Charatcharoenwitthaya N, Jaisamrarn U, Kuptniratsaikul V, Yang RS, Lin SY, Taguchi A, Mori S, Li-Yu J, Ang SB, Chan DC, Chan WS, Ng H, Chen JF, Tu ST, Chuang HH, Chang YF, Chen FP, Tsai KS, Ebeling PR, Marin F, Nistal Rodríguez FJ, Shi H, Hwang KR, Kim KK, Chung YS, Reid IR, Chandran M, Ferrari S, Lewiecki EM, Hew FL, Ho-Pham LT, Nguyen TV, Nguyen VH, Lekamwasam S, Pandey D, Bhadada S, Chen CH, Hwang JS, Wu CH. Tai TW, et al. Among authors: yang rs. Osteoporos Sarcopenia. 2024 Mar;10(1):3-10. doi: 10.1016/j.afos.2024.02.001. Epub 2024 Mar 16. Osteoporos Sarcopenia. 2024. PMID: 38690538 Free PMC article. Review.
Survey of awareness and attitudes to the management of fragility fractures among the membership of the Asia Pacific Orthopaedic Association.
Lee JK, Mitchell PJ, Ang SB, Mercado-Asis LB, Rey-Matias R, Li J, Flicker L, Leung E, Choon D, Chandrasekaran SK, Close JCT, Seymour H, Cooper C, Halbout P, Blank RD, Zhao Y, Malhotra R, Unnanuntana A, Woo YL, Noor Z, Yang RS, Tabu I, Islam SS, Chinoy MA, Pande S, Thapa B, Wong RMY, Pande K, Chan DD; Asia Pacific Fragility Fracture Alliance and the Asia Pacific Osteoporosis and Fragility Fracture Society. Lee JK, et al. Among authors: yang rs. Arch Osteoporos. 2024 Apr 2;19(1):24. doi: 10.1007/s11657-024-01375-6. Arch Osteoporos. 2024. PMID: 38565791
Sequential multimodal treatments with chemotherapy and surgery for advanced soft tissue sarcoma may be associated with better survival than chemotherapy.
Chen CT, Chen HW, Lin WH, Huang PM, Lin MW, Yang CY, Hsu CY, Wang CC, Lee JC, Chang K, Huang KH, Chen HM, Chen TW, Yang RS, Hong RL. Chen CT, et al. Among authors: yang rs. J Formos Med Assoc. 2024 Mar 23:S0929-6646(24)00152-9. doi: 10.1016/j.jfma.2024.03.007. Online ahead of print. J Formos Med Assoc. 2024. PMID: 38521760 Free article.
Mosaic quadrivalent influenza vaccine single nanoparticle characterization.
Yang RS, Traver M, Barefoot N, Stephens T, Alabanza C, Manzella-Lapeira J, Zou G, Wolff J, Li Y, Resto M, Shadrick W, Yang Y, Ivleva VB, Tsybovsky Y, Carlton K, Brzostowski J, Gall JG, Lei QP. Yang RS, et al. Sci Rep. 2024 Feb 24;14(1):4534. doi: 10.1038/s41598-024-54876-2. Sci Rep. 2024. PMID: 38402303 Free PMC article.
Engineering Hydroxylase Activity, Selectivity, and Stability for a Scalable Concise Synthesis of a Key Intermediate to Belzutifan.
Cheung-Lee WL, Kolev JN, McIntosh JA, Gil AA, Pan W, Xiao L, Velásquez JE, Gangam R, Winston MS, Li S, Abe K, Alwedi E, Dance ZEX, Fan H, Hiraga K, Kim J, Kosjek B, Le DN, Marzijarani NS, Mattern K, McMullen JP, Narsimhan K, Vikram A, Wang W, Yan JX, Yang RS, Zhang V, Zhong W, DiRocco DA, Morris WJ, Murphy GS, Maloney KM. Cheung-Lee WL, et al. Among authors: yang rs. Angew Chem Int Ed Engl. 2024 Mar 22;63(13):e202316133. doi: 10.1002/anie.202316133. Epub 2024 Feb 19. Angew Chem Int Ed Engl. 2024. PMID: 38279624
494 results