Yang LL - Search Results

1

X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease.

Ning XL, Li YZ, Huo C, Deng J, Gao C, Zhu KR, Wang M, Wu YX, Yu JL, Ren YL, Luo ZY, Li G, Chen Y, Wang SY, Peng C, Yang LL, Wang ZY, Wu Y, Qian S, Li GB. Ning XL, et al. Among authors: yang ll. J Med Chem. 2021 Jun 24;64(12):8303-8332. doi: 10.1021/acs.jmedchem.1c00303. Epub 2021 Jun 10. J Med Chem. 2021. PMID: 34110158

2

Discovery of novel mGluR1 antagonists: a multistep virtual screening approach based on an SVM model and a pharmacophore hypothesis significantly increases the hit rate and enrichment factor.

Li GB, Yang LL, Feng S, Zhou JP, Huang Q, Xie HZ, Li LL, Yang SY. Li GB, et al. Among authors: yang sy, yang ll. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1736-40. doi: 10.1016/j.bmcl.2011.01.087. Epub 2011 Jan 25. Bioorg Med Chem Lett. 2011. PMID: 21316965

3

Discovery of the novel potent and selective FLT3 inhibitor 1-{5-[7-(3- morpholinopropoxy)quinazolin-4-ylthio]-[1,3,4]thiadiazol-2-yl}-3-p-tolylurea and its anti-acute myeloid leukemia (AML) activities in vitro and in vivo.

Li WW, Wang XY, Zheng RL, Yan HX, Cao ZX, Zhong L, Wang ZR, Ji P, Yang LL, Wang LJ, Xu Y, Liu JJ, Yang J, Zhang CH, Ma S, Feng S, Sun QZ, Wei YQ, Yang SY. Li WW, et al. Among authors: yang sy, yang ll, yang j. J Med Chem. 2012 Apr 26;55(8):3852-66. doi: 10.1021/jm300042x. Epub 2012 Apr 6. J Med Chem. 2012. PMID: 22452518

4

Discovery of N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit-to-lead optimization.

Yang LL, Li GB, Yan HX, Sun QZ, Ma S, Ji P, Wang ZR, Feng S, Zou J, Yang SY. Yang LL, et al. Among authors: yang sy. Eur J Med Chem. 2012 Oct;56:30-8. doi: 10.1016/j.ejmech.2012.08.007. Epub 2012 Aug 14. Eur J Med Chem. 2012. PMID: 22944772

5

Synthesis and characterization of 5,7-dihydroxyflavanone derivatives as novel protein tyrosine phosphatase 1B inhibitors.

Sun LP, Ma WP, Gao LX, Yang LL, Quan YC, Li J, Piao HR. Sun LP, et al. Among authors: yang ll. J Enzyme Inhib Med Chem. 2013 Dec;28(6):1199-204. doi: 10.3109/14756366.2012.723206. Epub 2012 Sep 26. J Enzyme Inhib Med Chem. 2013. PMID: 23009604

6

Structure-activity relationship studies of pyrazolo[3,4-d]pyrimidine derivatives leading to the discovery of a novel multikinase inhibitor that potently inhibits FLT3 and VEGFR2 and evaluation of its activity against acute myeloid leukemia in vitro and in vivo.

Yang LL, Li GB, Ma S, Zou C, Zhou S, Sun QZ, Cheng C, Chen X, Wang LJ, Feng S, Li LL, Yang SY. Yang LL, et al. Among authors: yang sy. J Med Chem. 2013 Feb 28;56(4):1641-55. doi: 10.1021/jm301537p. Epub 2013 Feb 19. J Med Chem. 2013. PMID: 23362959

7

ID-Score: a new empirical scoring function based on a comprehensive set of descriptors related to protein-ligand interactions.

Li GB, Yang LL, Wang WJ, Li LL, Yang SY. Li GB, et al. Among authors: yang sy, yang ll. J Chem Inf Model. 2013 Mar 25;53(3):592-600. doi: 10.1021/ci300493w. Epub 2013 Feb 26. J Chem Inf Model. 2013. PMID: 23394072

8

SC-535, a novel oral multikinase inhibitor, showed potent antitumor activity in human melanoma models.

Chen X, Ji P, Yang HW, Yang LL, Zhou S, Zhong L, Ma S, Fu XY, Zhou C, Li GB, Zheng MW, Wei YQ, Yang SY. Chen X, et al. Among authors: yang sy, yang ll, yang hw. Cell Physiol Biochem. 2013;32(1):138-53. doi: 10.1159/000350123. Epub 2013 Jul 12. Cell Physiol Biochem. 2013. PMID: 23867251 Free article.

9

A combined molecular docking-based and pharmacophore-based target prediction strategy with a probabilistic fusion method for target ranking.

Li GB, Yang LL, Xu Y, Wang WJ, Li LL, Yang SY. Li GB, et al. Among authors: yang sy, yang ll. J Mol Graph Model. 2013 Jul;44:278-85. doi: 10.1016/j.jmgm.2013.07.005. Epub 2013 Jul 23. J Mol Graph Model. 2013. PMID: 23933279

10

Synthesis and structure-activity relationship of non-phosphorus-based fructose-1,6-bisphosphatase inhibitors: 2,5-Diphenyl-1,3,4-oxadiazoles.

Liao BR, He HB, Yang LL, Gao LX, Chang L, Tang J, Li JY, Li J, Yang F. Liao BR, et al. Among authors: yang f, yang ll. Eur J Med Chem. 2014 Aug 18;83:15-25. doi: 10.1016/j.ejmech.2014.06.011. Epub 2014 Jun 10. Eur J Med Chem. 2014. PMID: 24946215

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