Yang LL - Search Results

1

Xu Y, Yang LL, Yang SY, Liu J. Xu Y, et al. Among authors: yang sy, yang ll. Acta Crystallogr Sect E Struct Rep Online. 2012 Jan;68(Pt 1):o162. doi: 10.1107/S1600536811053517. Epub 2011 Dec 17. Acta Crystallogr Sect E Struct Rep Online. 2012. PMID: 22259447 Free PMC article.

2

Discovery of the novel potent and selective FLT3 inhibitor 1-{5-[7-(3- morpholinopropoxy)quinazolin-4-ylthio]-[1,3,4]thiadiazol-2-yl}-3-p-tolylurea and its anti-acute myeloid leukemia (AML) activities in vitro and in vivo.

Li WW, Wang XY, Zheng RL, Yan HX, Cao ZX, Zhong L, Wang ZR, Ji P, Yang LL, Wang LJ, Xu Y, Liu JJ, Yang J, Zhang CH, Ma S, Feng S, Sun QZ, Wei YQ, Yang SY. Li WW, et al. Among authors: yang sy, yang ll, yang j. J Med Chem. 2012 Apr 26;55(8):3852-66. doi: 10.1021/jm300042x. Epub 2012 Apr 6. J Med Chem. 2012. PMID: 22452518

3

A combined molecular docking-based and pharmacophore-based target prediction strategy with a probabilistic fusion method for target ranking.

Li GB, Yang LL, Xu Y, Wang WJ, Li LL, Yang SY. Li GB, et al. Among authors: yang sy, yang ll. J Mol Graph Model. 2013 Jul;44:278-85. doi: 10.1016/j.jmgm.2013.07.005. Epub 2013 Jul 23. J Mol Graph Model. 2013. PMID: 23933279

4

ID-Score: a new empirical scoring function based on a comprehensive set of descriptors related to protein-ligand interactions.

Li GB, Yang LL, Wang WJ, Li LL, Yang SY. Li GB, et al. Among authors: yang sy, yang ll. J Chem Inf Model. 2013 Mar 25;53(3):592-600. doi: 10.1021/ci300493w. Epub 2013 Feb 26. J Chem Inf Model. 2013. PMID: 23394072

5

Taking quinazoline as a general support-Nog to design potent and selective kinase inhibitors: application to FMS-like tyrosine kinase 3.

Li WW, Chen JJ, Zheng RL, Zhang WQ, Cao ZX, Yang LL, Qing XY, Zhou LX, Yang L, Yu LD, Chen LJ, Wei YQ, Yang SY. Li WW, et al. Among authors: yang sy, yang l, yang ll. ChemMedChem. 2010 Apr 6;5(4):513-6. doi: 10.1002/cmdc.200900537. ChemMedChem. 2010. PMID: 20140937 No abstract available.

6

Discovery of novel mGluR1 antagonists: a multistep virtual screening approach based on an SVM model and a pharmacophore hypothesis significantly increases the hit rate and enrichment factor.

Li GB, Yang LL, Feng S, Zhou JP, Huang Q, Xie HZ, Li LL, Yang SY. Li GB, et al. Among authors: yang sy, yang ll. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1736-40. doi: 10.1016/j.bmcl.2011.01.087. Epub 2011 Jan 25. Bioorg Med Chem Lett. 2011. PMID: 21316965

7

Combined SVM-based and docking-based virtual screening for retrieving novel inhibitors of c-Met.

Xie QQ, Zhong L, Pan YL, Wang XY, Zhou JP, Di-Wu L, Huang Q, Wang YL, Yang LL, Xie HZ, Yang SY. Xie QQ, et al. Among authors: yang sy, yang ll. Eur J Med Chem. 2011 Sep;46(9):3675-80. doi: 10.1016/j.ejmech.2011.05.031. Epub 2011 May 25. Eur J Med Chem. 2011. PMID: 21641696

8

Discovery of N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit-to-lead optimization.

Yang LL, Li GB, Yan HX, Sun QZ, Ma S, Ji P, Wang ZR, Feng S, Zou J, Yang SY. Yang LL, et al. Among authors: yang sy. Eur J Med Chem. 2012 Oct;56:30-8. doi: 10.1016/j.ejmech.2012.08.007. Epub 2012 Aug 14. Eur J Med Chem. 2012. PMID: 22944772

9

Structure-activity relationship studies of pyrazolo[3,4-d]pyrimidine derivatives leading to the discovery of a novel multikinase inhibitor that potently inhibits FLT3 and VEGFR2 and evaluation of its activity against acute myeloid leukemia in vitro and in vivo.

Yang LL, Li GB, Ma S, Zou C, Zhou S, Sun QZ, Cheng C, Chen X, Wang LJ, Feng S, Li LL, Yang SY. Yang LL, et al. Among authors: yang sy. J Med Chem. 2013 Feb 28;56(4):1641-55. doi: 10.1021/jm301537p. Epub 2013 Feb 19. J Med Chem. 2013. PMID: 23362959

10

SC-535, a novel oral multikinase inhibitor, showed potent antitumor activity in human melanoma models.

Chen X, Ji P, Yang HW, Yang LL, Zhou S, Zhong L, Ma S, Fu XY, Zhou C, Li GB, Zheng MW, Wei YQ, Yang SY. Chen X, et al. Among authors: yang sy, yang ll, yang hw. Cell Physiol Biochem. 2013;32(1):138-53. doi: 10.1159/000350123. Epub 2013 Jul 12. Cell Physiol Biochem. 2013. PMID: 23867251 Free article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

835 results

Search Page