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The novel synthesized 2-(3-(methylamino)phenyl)-6-(pyrrolidin-1-yl)quinolin-4-one (Smh-3) compound induces G2/M phase arrest and mitochondrial-dependent apoptotic cell death through inhibition of CDK1 and AKT activity in HL-60 human leukemia cells.
Huang SM, Yang JS, Tsai SC, Chen MH, Hsu MH, Lin HY, Chou LC, Chinag JH, Lee KH, Huang LJ, Kuo SC. Huang SM, et al. Among authors: yang js. Int J Oncol. 2011 May;38(5):1357-64. doi: 10.3892/ijo.2011.952. Epub 2011 Feb 22. Int J Oncol. 2011. PMID: 21344160
The novel synthesized 6-fluoro-(3-fluorophenyl)-4-(3-methoxyanilino)quinazoline (LJJ-10) compound exhibits anti-metastatic effects in human osteosarcoma U-2 OS cells through targeting insulin-like growth factor-I receptor.
Chen KT, Hour MJ, Tsai SC, Chung JG, Kuo SC, Lu CC, Chiu YJ, Chuang YH, Yang JS. Chen KT, et al. Among authors: yang js. Int J Oncol. 2011 Sep;39(3):611-9. doi: 10.3892/ijo.2011.1071. Epub 2011 Jun 8. Int J Oncol. 2011. PMID: 21667022
Activations of Both Extrinsic and Intrinsic Pathways in HCT 116 Human Colorectal Cancer Cells Contribute to Apoptosis through p53-Mediated ATM/Fas Signaling by Emilia sonchifolia Extract, a Folklore Medicinal Plant.
Lan YH, Chiang JH, Huang WW, Lu CC, Chung JG, Wu TS, Jhan JH, Lin KL, Pai SJ, Chiu YJ, Tsuzuki M, Yang JS. Lan YH, et al. Among authors: yang js. Evid Based Complement Alternat Med. 2012;2012:178178. doi: 10.1155/2012/178178. Epub 2012 Feb 28. Evid Based Complement Alternat Med. 2012. PMID: 22474491 Free PMC article.
1,816 results