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Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract.
Zhang J, Walker ME, Sanidad KZ, Zhang H, Liang Y, Zhao E, Chacon-Vargas K, Yeliseyev V, Parsonnet J, Haggerty TD, Wang G, Simpson JB, Jariwala PB, Beaty VV, Yang J, Yang H, Panigrahy A, Minter LM, Kim D, Gibbons JG, Liu L, Li Z, Xiao H, Borlandelli V, Overkleeft HS, Cloer EW, Major MB, Goldfarb D, Cai Z, Redinbo MR, Zhang G. Zhang J, et al. Among authors: yang h, yang j. Nat Commun. 2022 Jan 10;13(1):136. doi: 10.1038/s41467-021-27762-y. Nat Commun. 2022. PMID: 35013263 Free PMC article.
Effects of high-fat diet on plasma profiles of eicosanoid metabolites in mice.
Wang W, Yang J, Yang H, Sanidad KZ, Hammock BD, Kim D, Zhang G. Wang W, et al. Among authors: yang h, yang j. Prostaglandins Other Lipid Mediat. 2016 Dec;127:9-13. doi: 10.1016/j.prostaglandins.2016.11.003. Epub 2016 Nov 30. Prostaglandins Other Lipid Mediat. 2016. PMID: 27913146 Free PMC article.
Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation.
Wang W, Yang J, Zhang J, Wang Y, Hwang SH, Qi W, Wan D, Kim D, Sun J, Sanidad KZ, Yang H, Park Y, Liu JY, Zhao X, Zheng X, Liu Z, Hammock BD, Zhang G. Wang W, et al. Among authors: yang h, yang j. Proc Natl Acad Sci U S A. 2018 May 15;115(20):5283-5288. doi: 10.1073/pnas.1721711115. Epub 2018 May 1. Proc Natl Acad Sci U S A. 2018. PMID: 29717038 Free PMC article.
A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice.
Yang H, Wang W, Romano KA, Gu M, Sanidad KZ, Kim D, Yang J, Schmidt B, Panigrahy D, Pei R, Martin DA, Ozay EI, Wang Y, Song M, Bolling BW, Xiao H, Minter LM, Yang GY, Liu Z, Rey FE, Zhang G. Yang H, et al. Among authors: yang gy, yang j. Sci Transl Med. 2018 May 30;10(443):eaan4116. doi: 10.1126/scitranslmed.aan4116. Sci Transl Med. 2018. PMID: 29848663 Free PMC article.
Targeted Metabolomics Identifies the Cytochrome P450 Monooxygenase Eicosanoid Pathway as a Novel Therapeutic Target of Colon Tumorigenesis.
Wang W, Yang J, Edin ML, Wang Y, Luo Y, Wan D, Yang H, Song CQ, Xue W, Sanidad KZ, Song M, Bisbee HA, Bradbury JA, Nan G, Zhang J, Shih PB, Lee KSS, Minter LM, Kim D, Xiao H, Liu JY, Hammock BD, Zeldin DC, Zhang G. Wang W, et al. Among authors: yang h, yang j. Cancer Res. 2019 Apr 15;79(8):1822-1830. doi: 10.1158/0008-5472.CAN-18-3221. Epub 2019 Feb 25. Cancer Res. 2019. PMID: 30803995 Free PMC article.
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