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Structure-based discovery of 1-(3-fluoro-5-(5-(3-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)phenyl)-3-(pyrimidin-5-yl)urea as a potent and selective nanomolar type-II PLK4 inhibitor.
Sun Y, Wang L, Sun Y, Wang J, Xue Y, Wu T, Yin W, Qin Q, Sun Y, Wang H, Gao Y, Yang H, Zhao D, Cheng M. Sun Y, et al. Among authors: yang h. Eur J Med Chem. 2022 Dec 5;243:114714. doi: 10.1016/j.ejmech.2022.114714. Epub 2022 Aug 30. Eur J Med Chem. 2022. PMID: 36063666
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