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SIK2 inhibition enhances PARP inhibitor activity synergistically in ovarian and triple-negative breast cancers.
Lu Z, Mao W, Yang H, Santiago-O'Farrill JM, Rask PJ, Mondal J, Chen H, Ivan C, Liu X, Liu CG, Xi Y, Masuda K, Carrami EM, Chen M, Tang Y, Pang L, Lakomy DS, Calin GA, Liang H, Ahmed AA, Vankayalapati H, Bast RC Jr. Lu Z, et al. Among authors: yang h. J Clin Invest. 2022 Jun 1;132(11):e146471. doi: 10.1172/JCI146471. J Clin Invest. 2022. PMID: 35642638 Free PMC article.
ARHI (DIRAS3) induces autophagy in ovarian cancer cells by downregulating the epidermal growth factor receptor, inhibiting PI3K and Ras/MAP signaling and activating the FOXo3a-mediated induction of Rab7.
Lu Z, Yang H, Sutton MN, Yang M, Clarke CH, Liao WS, Bast RC Jr. Lu Z, et al. Among authors: yang m, yang h. Cell Death Differ. 2014 Aug;21(8):1275-89. doi: 10.1038/cdd.2014.48. Epub 2014 Apr 25. Cell Death Differ. 2014. PMID: 24769729 Free PMC article.
CDK5 Regulates Paclitaxel Sensitivity in Ovarian Cancer Cells by Modulating AKT Activation, p21Cip1- and p27Kip1-Mediated G1 Cell Cycle Arrest and Apoptosis.
Zhang S, Lu Z, Mao W, Ahmed AA, Yang H, Zhou J, Jennings N, Rodriguez-Aguayo C, Lopez-Berestein G, Miranda R, Qiao W, Baladandayuthapani V, Li Z, Sood AK, Liu J, Le XF, Bast RC Jr. Zhang S, et al. Among authors: yang h. PLoS One. 2015 Jul 6;10(7):e0131833. doi: 10.1371/journal.pone.0131833. eCollection 2015. PLoS One. 2015. PMID: 26146988 Free PMC article.
A Novel Compound ARN-3236 Inhibits Salt-Inducible Kinase 2 and Sensitizes Ovarian Cancer Cell Lines and Xenografts to Paclitaxel.
Zhou J, Alfraidi A, Zhang S, Santiago-O'Farrill JM, Yerramreddy Reddy VK, Alsaadi A, Ahmed AA, Yang H, Liu J, Mao W, Wang Y, Takemori H, Vankayalapati H, Lu Z, Bast RC Jr. Zhou J, et al. Among authors: yang h. Clin Cancer Res. 2017 Apr 15;23(8):1945-1954. doi: 10.1158/1078-0432.CCR-16-1562. Epub 2016 Sep 27. Clin Cancer Res. 2017. PMID: 27678456 Free PMC article.
In Vivo Optical Detection and Spectral Triangulation of Carbon Nanotubes.
Lin CW, Yang H, Sanchez SR, Mao W, Pang L, Beckingham KM, Bast RC Jr, Weisman RB. Lin CW, et al. Among authors: yang h. ACS Appl Mater Interfaces. 2017 Dec 6;9(48):41680-41690. doi: 10.1021/acsami.7b12916. Epub 2017 Nov 27. ACS Appl Mater Interfaces. 2017. PMID: 29131572
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